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Deuterium labeling of glyprolines by isotope exchange

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Abstract

Deuterium-labeled 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-Pro-NH2, and Phe-Pro-LeuPro-Ala were synthesized. The effect of the method of peptide deposition on the catalyst, the catalyst nature, temperature, and structure of peptides on the inclusion of deuterium with the formation of the appropriate number of isotopomers was demonstrated. The 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-Pro-NH2, and Phe-Pro-Leu-Pro-Ala peptides containing, on average, 4.6, 7.7, and 5.4 deuterium atoms per peptide molecule, respectively, were obtained.

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References

  1. Andreeva, L.A., Nagaev, I.Yu., Shevchenko, V.P., and Myasoedov, N.F., Abstracts of Papers, VII Rosssiiskii simpozium “Belki i peptidy” (VII Russian Symposiym “Proteins and Peptides”), Novosibirsk, 2015, p. 288.

    Google Scholar 

  2. Shevchenko, K.V., Andreeva, L.A., Nagaev, I.Yu., Shevchenko, V.P., and Myasoedov, N.F., Abstracts of Papers, VIMezhdunarodnaya konferentsiya “Biologicheskie osnovy individual’noi chuvstvitel’nosti k psikhotropnym sredstvam” (VI International Conference “Biological Foundations of Individual Sensitivity to Psychotropic Drugs”), Moscow, 2015.

    Google Scholar 

  3. Shevchenko, V.P., Nagaev, I.Yu., and Myasoedov, N.F., J. Label. Comp. Radiopharm., 2010, vol. 53, no. 11/12, pp. 693–703.

    Article  CAS  Google Scholar 

  4. Shevchenko, V.P., Nagaev, I.Yu., Shevchenko, K.V., Chernysheva, M.G., Badun, G.A., Fedoseev, V.M., and Myasoedov, N.F., Radiokhimiya, 2011, vol. 53, no. 3, pp. 285–288.

    Google Scholar 

  5. Shevchenko, V.P., Nagaev, I.Yu., Shevchenko, K.V., and Myasoedov, N.F., Radiokhimiya, 2013, vol. 55, no. 3, pp. 284–288.

    Google Scholar 

  6. Chiesa, M., Paganini, M.C., Spoto, G., Giamello, E., Di Valentin, C., Del Vitto, A., and Pacchioni, G., J. Phys. Chem. B, 2005, vol. 109, no. 15, pp. 7314–7322.

    Article  CAS  Google Scholar 

  7. Shevchenko, V.P., Nagaev, I.Yu., and Myasoedov, N.F., Usp. Khim., 2003, vol. 72, no. 5, pp. 471–497.

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 2, Moscow, 123182, Russia

    V. P. Shevchenko, I. Yu. Nagaev, K. V. Shevchenko & N. F. Myasoedov

Authors
  1. V. P. Shevchenko
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  2. I. Yu. Nagaev
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  3. K. V. Shevchenko
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  4. N. F. Myasoedov
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Corresponding author

Correspondence to I. Yu. Nagaev.

Additional information

Original Russian Text © V.P. Shevchenko, I.Yu. Nagaev, K.V. Shevchenko, N.F. Myasoedov, 2016, published in Doklady Akademii Nauk, 2016, Vol. 466, No. 6, pp. 683–687.

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Shevchenko, V.P., Nagaev, I.Y., Shevchenko, K.V. et al. Deuterium labeling of glyprolines by isotope exchange. Dokl Chem 466, 48–52 (2016). https://doi.org/10.1134/S0012500816020087

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  • DOI: https://doi.org/10.1134/S0012500816020087

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