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The effect of dopamine on in vitro methemoglobin formation in erythrocytes of patients with Parkinson’s disease under oxidative stress

  • Cell Biophysics
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Abstract

Using electron paramagnetic resonance, the dose-dependence effect of dopamine on methemoglobin formation in erythrocytes of patients with Parkinson’s disease under the activation of oxidative stress induced by acrolein and the possibilities for the correction of this pathological process using carnosine in vitro experiments have been examined. It was shown that incubation of erythrocytes with 1.5 mM dopamine did not change the methemoglobin content, while incubation with 15 mM dopamine caused a two fold increase in the methemoglobin content compared to its initial level; 10 μM acrolein increased methemoglobin formation threefold. Administration of 15 mM dopamine and, after 1 h, 10 μM acrolein to the incubation system increased methemoglobin formation tenfold compared to its initial level. Preincubation of erythrocytes with 5 mM carnosine followed by acrolein addition prevented the increase in the methemoglobin content, while carnosine had no effect on methemoglobin formation induced by dopamine.

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Abbreviations

PD:

Parkinson’s disease

OS:

oxidative stress

DOPA:

L-dihydroxyphenylalanine

ROS:

reactive oxygen species

MetHb:

methemoglobin

EPR:

electron paramagnetic resonance

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Authors and Affiliations

  1. Research Center of Neurology, Moscow, 125367, Russia

    M. G. Makletsova, T. N. Fedorova & V. V. Poleschuk

  2. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991, Russia

    G. T. Rikhireva

Authors
  1. M. G. Makletsova
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  2. T. N. Fedorova
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  3. V. V. Poleschuk
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  4. G. T. Rikhireva
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Corresponding authors

Correspondence to M. G. Makletsova or G. T. Rikhireva.

Additional information

Original Russian Text © M.G. Makletsova, T.N. Fedorova, V.V. Poleschuk, G.T. Rikhireva, 2017, published in Biofizika, 2017, Vol. 62, No. 2, pp. 319–324.

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Makletsova, M.G., Fedorova, T.N., Poleschuk, V.V. et al. The effect of dopamine on in vitro methemoglobin formation in erythrocytes of patients with Parkinson’s disease under oxidative stress. BIOPHYSICS 62, 247–251 (2017). https://doi.org/10.1134/S0006350917020154

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  • DOI: https://doi.org/10.1134/S0006350917020154

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