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Functional interactions of Na,K-ATPase with molecular environment

  • Cell Biophysics
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Abstract

The present review covers the analysis of research in the field of intermolecular interactions of Na,K-ATPase which underlie novel cellular regulatory mechanisms. The capability of Na,K-ATPase to form multimolecular regulatory complexes and take part as a scaffolding protein in formation of cell functional and signaling microcompartments is considered. Particular attention is directed to membrane lipid microdomains (rafts, caveolae). Mechanisms of signaling and neuroprotective functions of Na,K-ATPase as well as the involvement of endogenous cardiotonic steroids in their realization are discussed. This review demonstrates novel data on functional interactions of Na,K-ATPase with neurotransmitter receptors and other proteins involved in regulation of synaptic transmission.

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  1. St. Petersburg State University, St. Petersburg, 199034, Russia

    I. I. Krivoi

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Original Russian Text © I.I. Krivoi, 2014, published in Biofizika, 2014, Vol. 59, No. 5, pp. 871–882.

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Krivoi, I.I. Functional interactions of Na,K-ATPase with molecular environment. BIOPHYSICS 59, 708–717 (2014). https://doi.org/10.1134/S000635091405011X

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