Abstract
A computer simulation study is made on mutual synchronization of auto-oscillations of epidermal cell density in psoriatic skin lesions under conditions of strong clipped noise. The initial model is a system of three ordinary nonlinear differential equations, presumably describing the principles of paracrine regulation of epidermal proliferation with functionally activated CD4+/CD8+ lymphocytes. It is shown that, if epidermal proliferation is considered as an attribute determining the pathomorphological features of dermatoses, synchronization may prove responsible for development of linear, annular, arcuate, geographical psoriasis, and also the restricted and the disseminated forms of disease. It is shown that strong noise can shift the time of clinical manifestation of ensembles of synchronized psoriatic lesions by several days; the phase slip, up to tens of days; and differences in physical parameters, by several hours to several days.
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Original Russian Text © M.V. Laptev, N.K. Nikulin, 2012, published in Biofizika, 2012, Vol. 57, No. 4, pp. 713–725.
Editor’s Note: This work clearly stems from two previous publications by the same authors [Biophysics 54, 519 (2009) and 55, 305 (2010)] that for some reason were not referenced here. A.G.
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Laptev, M.V., Nikulin, N.K. Mutual synchronization of cell density auto-oscillations in psoriatic skin lesions in a model of paracrine regulation of epidermal proliferation involving T lymphocytes. BIOPHYSICS 57, 544–555 (2012). https://doi.org/10.1134/S0006350912040100
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DOI: https://doi.org/10.1134/S0006350912040100