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Nano-biomachine from actin and myosin gels

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Abstract

We introduce here an ATP (adenosine triphosphate)-fueled nano-biomachine constructed from actin and myosin gels. Various types of chemically cross-linked actin gel, which are tens of times larger in size than native actin filaments (F-actin), were formed by complexing with cation-polymers and placed on a chemically cross-linked myosin gel. By adding dilute solution of ATP, they moved along the myosin gel with a velocity as high as that of native F-actin by coupling to ATP hydrolysis. Formation mechanism and structure of actin complexes as well as those of myosin gels were studied in detail and elucidated with the specific characteristics of the motility. These results demonstrate that one can construct nano-biomachines fueled by chemical energy of ATP with controlled motility.

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Authors and Affiliations

  1. RIKEN, Advanced Science Institute, Hirosawa, Saitama, 351-0198, Japan

    Yoshihito Osada

  2. Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, 060-0810, Japan

    Jian Ping Gong

Authors
  1. Yoshihito Osada
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  2. Jian Ping Gong
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Correspondence to Yoshihito Osada.

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The text was submitted by the authors in English.

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Osada, Y., Gong, J.P. Nano-biomachine from actin and myosin gels. Polym. Sci. Ser. A 51, 689–700 (2009). https://doi.org/10.1134/S0965545X09060145

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  • DOI: https://doi.org/10.1134/S0965545X09060145

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