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Antiapoptotic effect of gangliosides on PC12 cells exposed to bacterial lipopolysaccharide

  • Comparative and Ontogenic Biochemistry
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Abstract

Lipopolysaccharide (LPS) from the Escherichia coli serotype 0111:B4 at concentrations of 0.1 and 0.125 mg/ml was shown to exert an apoptotic effect on the neuronal PC12 cell line in DMEM (serum free medium). Gangliosides GD1a and GM1 at a concentration of 100 μM were found to raise the PC12 cell line viability and decrease the percentage of PC12 cells in the late-phase apoptosis after exposure to LPS.

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Authors and Affiliations

  1. Sechenov Institute of Evolutional Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russia

    L. V. Bayunova, R. G. Parnova & N. F. Avrova

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  1. L. V. Bayunova
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  2. R. G. Parnova
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  3. N. F. Avrova
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Correspondence to L. V. Bayunova.

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Original Russian Text © L.V. Bayunova, R.G. Parnova, N.F. Avrova, 2015, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2015, Vol. 51, No. 2, pp. 88–95.

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Bayunova, L.V., Parnova, R.G. & Avrova, N.F. Antiapoptotic effect of gangliosides on PC12 cells exposed to bacterial lipopolysaccharide. J Evol Biochem Phys 51, 98–106 (2015). https://doi.org/10.1134/S0022093015020027

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  • DOI: https://doi.org/10.1134/S0022093015020027

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