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Relationship between self-organization and biological activity of highly diluted solutions of a tetrahydrazide tetrathiacalix[4]arene derivative

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Abstract

In the course of systematic study of self-organization and properties of diluted solutions of biologically active compounds (BACs), an unknown phenomenon has been discovered. Using a complex of physicochemical methods, it has been shown for the first time that diluted aqueous solutions of many BACs in a wide range of calculated concentrations (10–6–10–20 mol/L), prepared by serial tenfold dilution from a stock solution, are self-organized disperse systems in which the disperse phase is represented by nanosized molecular ensembles (up to 400 nm) denominated nanoassociates [1].

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References

  1. Konovalov, A.I. and Ryzhkina, I.S., Izv. Akad. Nauk, Ser. Khim., 2014, no. 1, pp. 1–14.

    Google Scholar 

  2. Ryzhkina I.S., Kiseleva Yu.V., Mishina O.A., Murtazina L.I., Litvinov, A.I., Kadirov, M.K., and Konovalov, A.I., Izv. Akad. Nauk, Ser. Khim., 2015, no. 3, pp. 579–589.

    Google Scholar 

  3. Ryzhkina, I.S., Kiseleva, Yu.V., Timosheva, A.P., Safiullin, R.A., Kadirov, M.K., Valitova, Yu.N., and Konovalov, A.I., Dokl. Phys. Chem., 2012, vol. 447, part 1, pp. 193–199.

    Article  CAS  Google Scholar 

  4. Sedlak, M. and Rak, D., J. Phys. Chem. B, 2013, vol. 117, p. 2495.

    Article  CAS  Google Scholar 

  5. Gall’, L.N., Fizicheskie printsipy funktsionirovaniya materii zhivogo organizma (Physical Principles of Functioning of a Matter of a Living Organism), St. Petersburg: Izd. Politekhn. Univ., 2014.

    Google Scholar 

  6. Ryzhkina, I.S., Kiseleva, Yu.V., Mishina, O.A., Timosheva, A.P., Sergeeva, S.Yu., Kravchenko, A.N., and Konovalov, A.I., Mendeleev Commun., 2013, no. 23, pp. 262–264.

    Article  CAS  Google Scholar 

  7. Ryzhkina, I.S., Mishina, O.A., Timosheva, A.P., Kiseleva, Yu.V., Voloshina, A.D., Kulik, N.V., and Konovalov, A.I., Dokl. Phys. Chem., 2014, vol. 459, part 1, pp. 166–172.

    Article  CAS  Google Scholar 

  8. Konovalov, A.I., Mal’tseva, E.L., Ryzhkina, I.S., Murtazina, L.I., Kiseleva, Yu.V., Kasparov, V.V., and Pal’mina, N.P., Dokl. Phys. Chem., 2014, vol. 456, part 2, pp. 86–89.

    Article  CAS  Google Scholar 

  9. Ryzhkina, I.S., Kiseleva, Yu.V., Mishina, O.A., Murtazina, L.I., Sudakova, S.N., Podyachev, S.N., and Konovalov, A.I., Dokl. Phys. Chem. 2013, vol. 453, part 1, pp. 264–269.

    Article  CAS  Google Scholar 

  10. Podyachev, S.N., Syakaev, V.V., Sudakova, S.N., Shagidullin, R.R., Osyanina, D.V., Avvakumova, L.V., Buzykin, B.I., Latypov, Sh.K., Habicher, V.D., and Konovalov, A.I., J. Inclusion Phenom., 2007, no. 58, pp. 55–61.

    Article  CAS  Google Scholar 

  11. Semenov, V.E., Voloshina, A.D., and Toroptzova, E.M., Eur. J. Med. Chem., 2006, no. 41, p. 1093.

    Article  CAS  Google Scholar 

  12. Gordon, L.Kh., Valitova, Yu.N., Ogorodnikova, T.I., et al., Tsitologiya, 2005, vol. 47, no. 12, pp. 1088–1094.

    CAS  Google Scholar 

  13. Konovalov, A.I., Ryzhkina, I.S., and Murtazina, L.I., Byul. Izobr., 2010, no. 24.

    Google Scholar 

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Authors and Affiliations

  1. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences, ul. Akademika Arbuzova 8, Kazan, 420088, Tatarstan, Russia

    I. S. Ryzhkina, Yu. V. Kiseleva, O. A. Mishina, A. D. Voloshina, N. V. Kulik, Yu. N. Valitova, S. N. Sudakova, S. N. Podyachev, V. V. Zobov & A. I. Konovalov

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  1. I. S. Ryzhkina
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  2. Yu. V. Kiseleva
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  3. O. A. Mishina
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  4. A. D. Voloshina
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  5. N. V. Kulik
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  6. Yu. N. Valitova
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  7. S. N. Sudakova
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  8. S. N. Podyachev
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  9. V. V. Zobov
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  10. A. I. Konovalov
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Corresponding author

Correspondence to I. S. Ryzhkina.

Additional information

Original Russian Text © I.S. Ryzhkina, Yu.V. Kiseleva, O.A. Mishina, A.D. Voloshina, N.V. Kulik, Yu.N. Valitova, S.N. Sudakova, S.N. Podyachev, V.V. Zobov, A.I. Konovalov, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 6, pp. 700–704.

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Ryzhkina, I.S., Kiseleva, Y.V., Mishina, O.A. et al. Relationship between self-organization and biological activity of highly diluted solutions of a tetrahydrazide tetrathiacalix[4]arene derivative. Dokl Phys Chem 464, 251–254 (2015). https://doi.org/10.1134/S0012501615100085

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  • DOI: https://doi.org/10.1134/S0012501615100085

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