Abstract
In this research we investigate neuroblastoma cells cultivated on single-walled carbon nanotubes networks made by CVD method on silicon substrates. The complex analysis of grown cells made by atomic force, electron microscopy and Raman spectroscopy was carried out and the effect of nanotube growth process on proliferation factor was investigated. It is shown that despite of a weak decrease in proliferation, cell morphology remains unchanged and no physical or chemical interaction between carbon nanotubes and cells is observed. The results of the research can be used to investigate the interaction between conductive nano- materials and cells for the development of neural replacement implants. Also they can be useful in bio-electronic interface investigation of signal propagation in neurons.
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References
E. Olakowska, I. Woszczycka-Korczyn-ska, H. Jędrzejowska-Szypulka, and J. Lewin-Kowalik, Folia Neuropathol. 48(4), 231 (2010).
Z. Yang, Y. Zhang, Y. Yang, et al., Nanomedicine 6(3), 427 (2010).
B. S. Harrison and A. Atala, Biomaterials 28(2), 344 (2007).
P. X. Ma, Adv. Drug Delivery Rev. 60(2), 184 (2008).
T. Dviro, B. P. Timko, D. S. Kohane, and R. Langer, Nature Nanotechnology 6(1), 13 (2011).
S. A. Ageeva, I. I. Bobrinetskiy, V. K. Nevolin, et al., Izv. VUZov. Elektronika, No. 5, 33 (2008).
F. L. Y. Yuen, G. Zak, S. D. Waldman, and A. Docoslis, Cytotechnology 56(1), 9 (2008).
C. M. Voge and J. P. Stegemann, J. Neural Eng. 8(1), 011001 (2011).
I. I. Bobrinetskiy, R. A. Morozov, A. S. Seleznev, et al., Biomed. Tekhol. Radioelektron., No.3, 41 (2012).
V. M. Podgaetsky, I. I. Bobrinetskiy, S. V. Selishchev, and V. K. Nevolin, Optical Memory and Neural Networks (Information Optics), 17(2), 147 (2008).
I. I. Bobrinetskiy, R. A. Morozov, A. S. Seleznev, et al., Byul. Eksperim. Biol. Med. 153(2), 227 (2012).
I. I. Bobrinetskiy, R. A. Morozov, A. S. Seleznev, et al., Klet. Transplant. Tkan. Inzhener. 6(1), 85 (2011).
I. I. Bobrinetskii, R. A. Morozov, V. M. Podgaetskii, et al., Biophysics 56, 194 (2011).
D. Zhang, Y. Peng, H. Qi, et al., Sensors and Actuators B: Chem. 136(1), 113 (2009).
D. Y. Lewitus, J. Landers, J. R. Branch, et al., Adv. Functional Mater. 21(14), 2624 (2011).
Engineering the Bioelectronic Interface Applications to Analyte Biosensing and Protein Detection, Ed. By J. J. Davis (Royal Society of Chemistry, 2009).
G. Lamura, A. Andreone, Y. Yang, et al., J. Phys. Chem. C 111, 15154 (2007).
M. S. Dresselhaus, G. Dresselhaus, R. Saito, and A. Jorio, Physics Reports 409, 47 (2005).
R. U. Kharbiev, Manual on Experimental (preclinical) Study of New Pharmacological Substances (Meditsina, Moscow, 2005) [in Russian].
A. Sucapane, G. Cellot, M. Prato, et al., J. Nanoneurosci. 1, 1 (2008).
V. Raffa, G. Ciofani, and S. Nitodas, Carbon. 46(12), 1600 (2008).
M. A. Hussain, M. A. Kabir, and A. K. Sood, Current Sci. 96(5), 664 (2009).
I. I. Bobrinetskiy and V. K. Nevolin, Mikrosistem. Tekhnika 4, 20 (2002).
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Original Russian Text © I.I. Bobrinetskiy, A.S. Seleznev, I.A. Gayduchenko, G.E. Fedorov, A.G. Domantovskiy, M.Yu. Presnyakov, R.Ya. Podchernyaeva, G.R. Mikhailova, I.A. Suetina, 2013, published in Biofizika, 2013, Vol. 58, No. 3, pp. 524–530.
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Bobrinetskiy, I.I., Seleznev, A.S., Gayduchenko, I.A. et al. The interaction between nerve cells and carbon nanotube networks made by CVD process investigation. BIOPHYSICS 58, 409–414 (2013). https://doi.org/10.1134/S0006350913030056
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DOI: https://doi.org/10.1134/S0006350913030056