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Synthesis and transformations of new 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives

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Abstract

Reactions of cyclohexane-1,3-diones with amines and aldehydes led to the formation of 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-diones containing alkylaryl, aryl, and hydroxy substituents in position 10. Transformations of 10-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-diones under oxidation with nitrous acid, reduction with zinc powder, as well as on heating in aprotic solvents and acetic, phosphoric, and polyphosphoric acids, were studied. NMR spectra of 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-diones having different substituents in positions 9 and 10 were analyzed.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul. Akademika Kuprevicha 5/2, Minsk, 220141, Belarus

    A. N. Pyrko

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  1. A. N. Pyrko
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Correspondence to A. N. Pyrko.

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Original Russian Text © A.N. Pyrko, 2008, published in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 8, pp. 1227–1236.

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Pyrko, A.N. Synthesis and transformations of new 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives. Russ J Org Chem 44, 1215–1224 (2008). https://doi.org/10.1134/S1070428008080198

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  • DOI: https://doi.org/10.1134/S1070428008080198

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