Abstract
A room-temperature ionic liquid (IL), 1-ethyl-3-methyl-imidazolium tetrafluoroborate (1E-3MI-TFB), used for the coating of a silica capillary enables one to reduce or invert the electroosmotic flow (EOF) in capillary zone electrophoresis. Excellent separations of amino acids and ary lalkanoic acids were obtained. Such separations could not be obtained in a naked capillary in the presence of the cationic surfactants cetyltrimethylammonium bromide (CTAB) or polycationic polymer hexadimethrine bromide (HDB). The results indicate that 1E-3MI-TFB not only modulates the EOF but also acts as a discriminator. Further experiments indicate that the interaction between hydrogen at C-2 carbon of IL and acid drugs plays an important role in the separation.
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Schwer, C. and Kenndler, E., Anal. Chem., 1991, vol. 63, no. 17, p. 1801.
Terabe, S., Otsuka, K., and Ando, T., Anal. Chem., 1985, vol. 57, no. 4, p. 834.
Hjertén, S., Elenbring, K., Kilár, F., and Liao, J.L., J. Chromatogr., 1987, vol. 403, nos. 1–2, p. 47.
Souza, S.R., Tavares, M.F.M., and Carvalho, L.R.F., J. Chromatogr., A, 1998, vol. 796, no. 2, p. 335.
Zlotorzynska, E.D., Piechowski, M., McGrath, M., and Lai, E.P.C., J. Chromatogr., A, 2001, vol. 910, no. 2, p. 331.
Huang, X.H., Luckey, J.A., Gordon, M.J., and Zare, R.N., Anal. Chem., 1989, vol. 61, no. 7, p. 766.
Kang, J.W., Yang, Y.T., You, J.M., and Ou, Q.Y., J. Chromatogr., A, 1998, vol. 825, no. 1, p. 81.
Welton, T., Chem. Rev., 1999, vol. 99, no. 80, p. 2071.
Brown, R.A., Pollet, P., Mckoon, E., and Eckert, C.A., J. Am. Chem. Soc., 2001, vol. 123, no. 6, p. 1254.
Xu, L.J., Chen, W.P., Ross, J., and Xiao, J.L., Org. Lett., 2001, vol. 3, no. 2, p. 295.
Fuller, J., Carlin, R.T., and Osteryoung, R.A., J. Electrochem. Soc., 1997, vol. 144, no. 11, p. 3881.
Sanders, J.R., Ward, E.H., and Husser, C.L., J. Electrochem. Soc., vol. 133, no. 2, p. 325.
Armstrong, D.W., Zhang, L.K., He, L.F., and Gross, M.L., Anal. Chem., 2001, vol. 73, no. 15, p. 3679.
Chun, S.K., Dzyuba, S.V., and Bartsch, R.A., Anal. Chem., vol. 73, no. 15, p. 3737.
Jonathan, G.H., Heather, D.W., Richard, P.S., Ann, E.V., and Robin, D.R., Chem. Commun., 1998, p. 1765.
Yanes, E.G., Gratz, S.R., Baldwin, M.J., Robison, S.E., and Stalcup, A.M., Anal. Chem., 2001, vol. 73, no. 16, p. 3838.
Vaher, M., Koel, M., and Kaljurand, M., Electrophoresis, 2002, vol. 23, p. 426.
Cabovska, B., Kreishman, G.P., Wassell, D.F., and Stalcup, A.M., J. Chromatogr., A, 2003, vol. 1007, p. 179.
Qin, W.D., Wei, H.P., and Li, S.F.Y., J. Chromatogr., A, 2003, vol. 985, p. 447.
Jiang, T.F., Gu, Y.L., Liang, B., Li, J.B., Shi, Y.P., and Ou, Q.Y., Anal. Chim. Acta, 2003, vol. 479, p. 249.
Jiang, T.F., Lu, H.J., Li, J.B., Li, C., and Ou, Q.Y., Chin. J. Anal. Chem., 2002, vol. 30, p. 144.
Liu, J.F. and Ducker, W., J. Phys. Chem., B, 1999, vol. 103, no. 40, p. 8558.
Manne, S. and Gaub, H.E., Science, 1995, vol. 270, no. 5241, p. 1480.
Fuller, J., Carlin, R.T., Long, H.C., and Haworth, D., J. Chem. Soc., Chem. Commun., 1994, p. 299.
Hitchcock, P.B., Seddon, K.R., and Welton, T., J. Chem. Soc., Dalton Trans., 1993, p. 2639.
Wilkes, J.S. and Zaworotko, M.J., J. Chem. Soc., Chem. Commun., 1992, p. 965.
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Jiang, T.F., Wang, Y.H. & Lv, Z.H. Dynamic coating of a capillary with room-temperature ionic liquids for the separation of amino acids and acid drugs by capillary electrophoresis. J Anal Chem 61, 1108–1112 (2006). https://doi.org/10.1134/S1061934806110128
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DOI: https://doi.org/10.1134/S1061934806110128