Abstract
A significant number of post-transcriptional changes occur during the generation of mature transfer RNAs (tRNAs). These changes within precursor-tRNA molecules include the processing of 5′ and 3′ termini, the introduction of modifications, and also RNA editing. In this review, we will detail the reported cases of A-to-I and C-to-U tRNA editing. The most widespread example is the A-to-I conversion of the tRNA anticodon wobble base mediated by TadA in prokaryotes and the heterodimeric ADAT2-ADAT3 complex in eukaryotes. Recently, the plant chloroplast adenosine-to-inosine tRNA editing enzyme has been discovered. The editing of C-to-U is much less prevalent within tRNA and is currently only known to occur in few organellar tRNA species and the cytoplasmic threonyl-tRNA in trypanosomatids. The responsible editing enzyme remains to be identified. Finally, an unusually widespread C-to-U editing scenario was discovered in the archaeon Methanopyrus kandleri. This editing is mediated by CDAT8, which is responsible for the restoration of the proper folding of thirty different tRNA species. The evolution of CDAT8 will be discussed.
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Felsenfeld, G., and Cantoni, G. L. (1964) Proc. Natl. Acad. Sci. USA, 51, 818–826.
Kim, S. H., Quigley, G. J., Suddath, F. L., McPherson, A., Sneden, D., Kim, J. J., Weinzierl, J., and Rich, A. (1973) Science, 179, 285–288.
Ibba, M., and Soll, D. (2004) Genes Dev., 18, 731–738.
Ibba, M., and Soll, D. (1999) Science, 286, 1893–1897.
Agris, P. F., Vendeix, F. A., and Graham, W. D. (2007) J. Mol. Biol., 366, 1–13.
Li, H. (2007) Curr. Opin. Struct. Biol., 17, 293–301.
Hartmann, R. K., Gossringer, M., Spath, B., Fischer, S., and Marchfelder, A. (2009) Prog. Mol. Biol. Transl. Sci., 85, 319–368.
Soll, D. (1971) Science, 173, 293–299.
Fujishima, K., Sugahara, J., Kikuta, K., Hirano, R., Sato, A., Tomita, M., and Kanai, A. (2009) Proc. Natl. Acad. Sci. USA, 106, 2683–2687.
Randau, L., Calvin, K., Hall, M., Yuan, J., Podar, M., Li, H., and Soll, D. (2005) Proc. Natl. Acad. Sci. USA, 102, 17934–17939.
Randau, L., Munch, R., Hohn, M. J., Jahn, D., and Soll, D. (2005) Nature, 433, 537–541.
Maruyama, S., Sugahara, J., Kanai, A., and Nozaki, H. (2010) Mol. Biol. Evol., 27, 1070–1076.
Soma, A., Onodera, A., Sugahara, J., Kanai, A., Yachie, N., Tomita, M., Kawamura, F., and Sekine, Y. (2007) Science, 318, 450–453.
Lavrov, D. V., Brown, W. M., and Boore, J. L. (2000) Proc. Natl. Acad. Sci. USA, 97, 13738–13742.
Price, D. H., and Gray, M. W. (1999) RNA, 5, 302–317.
Byrne, E. M., and Gott, J. M. (2004) Mol. Cell. Biol., 24, 7821–7828.
Juhling, F., Morl, M., Hartmann, R. K., Sprinzl, M., Stadler, P. F., and Putz, J. (2009) Nucleic Acids Res., 37, D159–162.
Holley, R. W., Everett, G. A., Madison, J. T., and Zamir, A. (1965) J. Biol. Chem., 240, 2122–2128.
Grosjean, H., Auxilien, S., Constantinesco, F., Simon, C., Corda, Y., Becker, H. F., Foiret, D., Morin, A., Jin, Y. X., Fournier, M., and Fourrey, J. L. (1996) Biochimie, 78, 488–501.
Gerber, A., Grosjean, H., Melcher, T., and Keller, W. (1998) EMBO J., 17, 4780–4789.
Maas, S., Gerber, A. P., and Rich, A. (1999) Proc. Natl. Acad. Sci. USA, 96, 8895–8900.
Hundley, H. A., and Bass, B. L. (2010) Trends Biochem. Sci., 35, 377–383.
Macbeth, M. R., Schubert, H. L., Vandemark, A. P., Lingam, A. T., Hill, C. P., and Bass, B. L. (2005) Science, 309, 1534–1539.
Gerber, A. P., and Keller, W. (1999) Science, 286, 1146–1149.
Berman, H., Henrick, K., and Nakamura, H. (2003) Nat. Struct. Biol., 10, 980.
Yamaizumi, Z., Ihara, M., Kuchino, Y., Gupta, R., Woese, C. R., and Nishimura, S. (1982) Nucleic Acids Symp. Ser., 209–213.
Wolf, J., Gerber, A. P., and Keller, W. (2002) EMBO J., 21, 3841–3851.
Elias, Y., and Huang, R. H. (2005) Biochemistry, 44, 12057–12065.
Kuratani, M., Ishii, R., Bessho, Y., Fukunaga, R., Sengoku, T., Shirouzu, M., Sekine, S., and Yokoyama, S. (2005) J. Biol. Chem., 280, 16002–16008.
Lee, W. H., Kim, Y. K., Nam, K. H., Priyadarshi, A., Lee, E. H., Kim, E. E., Jeon, Y. H., Cheong, C., and Hwang, K. Y. (2007) Proteins, 68, 1016–1019.
Losey, H. C., Ruthenburg, A. J., and Verdine, G. L. (2006) Nat. Struct. Mol. Biol., 13, 153–159.
Karcher, D., and Bock, R. (2009) RNA, 15, 1251–1257.
Delannoy, E., Le Ret, M., Faivre-Nitschke, E., Estavillo, G. M., Bergdoll, M., Taylor, N. L., Pogson, B. J., Small, I., Imbault, P., and Gualberto, J. M. (2009) Plant Cell, 21, 2058–2071.
Binder, S., Marchfelder, A., and Brennicke, A. (1994) Mol. Gen. Genet., 244, 67–74.
Fey, J., Weil, J. H., Tomita, K., Cosset, A., Dietrich, A., Small, I., and Marechal-Drouard, L. (2001) Acta Biochim. Pol., 48, 383–389.
Fey, J., Weil, J. H., Tomita, K., Cosset, A., Dietrich, A., Small, I., and Marechal-Drouard, L. (2002) Gene, 286, 21–24.
Janke, A., and Paabo, S. (1993) Nucleic Acids Res., 21, 1523–1525.
Morl, M., Dorner, M., and Paabo, S. (1995) Nucleic Acids Res., 23, 3380–3384.
Alfonzo, J. D., Blanc, V., Estevez, A. M., Rubio, M. A., and Simpson, L. (1999) EMBO J., 18, 7056–7062.
Rubio, M. A., Ragone, F. L., Gaston, K. W., Ibba, M., and Alfonzo, J. D. (2006) J. Biol. Chem., 281, 115–120.
Gaston, K. W., Rubio, M. A., Spears, J. L., Pastar, I., Papavasiliou, F. N., and Alfonzo, J. D. (2007) Nucleic Acids Res., 35, 6740–6749.
Rubio, M. A., Pastar, I., Gaston, K. W., Ragone, F. L., Janzen, C. J., Cross, G. A., Papavasiliou, F. N., and Alfonzo, J. D. (2007) Proc. Natl. Acad. Sci. USA, 104, 7821–7826.
Randau, L., Stanley, B. J., Kohlway, A., Mechta, S., Xiong, Y., and Soll, D. (2009) Science, 324, 657–659.
Takai, K., Nakamura, K., Toki, T., Tsunogai, U., Miyazaki, M., Miyazaki, J., Hirayama, H., Nakagawa, S., Nunoura, T., and Horikoshi, K. (2008) Proc. Natl. Acad. Sci. USA, 105, 10949–10954.
Slesarev, A. I., Mezhevaya, K. V., Makarova, K. S., Polushin, N. N., Shcherbinina, O. V., Shakhova, V. V., Belova, G. I., Aravind, L., Natale, D. A., Rogozin, I. B., Tatusov, R. L., Wolf, Y. I., Stetter, K. O., Malykh, A. G., Koonin, E. V., and Kozyavkin, S. A. (2002) Proc. Natl. Acad. Sci. USA, 99, 4644–4649.
Sterner, T., Jansen, M., and Hou, Y. M. (1995) RNA, 1, 841–851.
Jones, C. N., Jones, C. I., Graham, W. D., Agris, P. F., and Spremulli, L. L. (2008) J. Biol. Chem., 283, 34445–34456.
Mattoccia, E., Baldi, I. M., Gandini-Attardi, D., Ciafre, S., and Tocchini-Valentini, G. P. (1988) Cell, 55, 731–738.
Palmer, J. R., Baltrus, T., Reeve, J. N., and Daniels, C. J. (1992) Biochim. Biophys. Acta, 1132, 315–318.
Burggraf, S., Stetter, K. O., Rouviere, P., and Woese, C. R. (1991) Syst. Appl. Microbiol., 14, 346–351.
Rivera, M. C., and Lake, J. A. (1996) Int. J. Syst. Bacteriol., 46, 348–351.
Brochier, C., Forterre, P., and Gribaldo, S. (2004) Genome Biol., 5, R17.
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Published in Russian in Biokhimiya, 2011, Vol. 76, No. 8, pp. 1142–1148.
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Su, A.A.H., Randau, L. A-to-I and C-to-U editing within transfer RNAs. Biochemistry Moscow 76, 932–937 (2011). https://doi.org/10.1134/S0006297911080098
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DOI: https://doi.org/10.1134/S0006297911080098