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Light damaging action of all-trans-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane

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Abstract

We have reproduced the model system containing A2-rhodopsin, NR-PE, A2-PE, and ATR-dimer-PE in order to study photosensitized damage of rhodopsin within photoreceptor membranes of rod outer segments. We have demonstrated that irradiation of such a system with visible light (400–700 nm) distorts the most important functional property of native visual pigment—its ability to regenerate after addition of 11-cis-retinal in the dark. We have also shown that all-trans-retinal bound to membrane phospholipids and rhodopsin has less photosensitizing activity that free all-trans-retinal.

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Abbreviations

ABCR:

ATP-binding cassette transporter

A2E:

N-bis-retinylidene-ethanolamine

A2-PE:

N-bis-retinylidene-phosphatidylethanolamine

A2-rhodopsin:

rhodopsin which has each of its three lysine residues modified with two all-trans-retinal molecules

ATR:

all-trans-retinal

ATR-dimer-PE:

all-trans-retinal-dimer-phosphatidylethanolamine

NR-PE:

N-retinylidene-phosphatidylethanolamine

ROS:

rod outer segments

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Authors and Affiliations

  1. Emanuel’ Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119334, Moscow, Russia

    M. Yu. Loginova, Ye. V. Rostovtseva, T. B. Feldman & M. A. Ostrovsky

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  1. M. Yu. Loginova
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  2. Ye. V. Rostovtseva
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  3. T. B. Feldman
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  4. M. A. Ostrovsky
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Correspondence to M. Yu. Loginova.

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Original Russian Text © M. Yu. Loginova, Ye. V. Rostovtseva, T. B. Feldman, M. A. Ostrovsky, 2008, published in Biokhimiya, 2008, Vol. 73, No. 2, pp. 162–172.

Originally published in Biochemistry (Moscow) On-Line Papers in Press, as Manuscript BM07-249, December 16, 2007.

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Loginova, M.Y., Rostovtseva, Y.V., Feldman, T.B. et al. Light damaging action of all-trans-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane. Biochemistry Moscow 73, 130–138 (2008). https://doi.org/10.1134/S000629790802003X

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  • DOI: https://doi.org/10.1134/S000629790802003X

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