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Molecular interactions of acute phase serum amyloid A: Possible involvement in carcinogenesis

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Abstract

Acute phase serum amyloid A (A-SAA) is a well-known marker of inflammation. The present review summarizes data on the regulation of A-SAA expression, signaling pathways which it is involved in, its effects, and possible influences on progression of malignant tumors.

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Abbreviations

A-SAA:

acute phase serum amyloid A

C/EBP:

CCAAT enhancer binding protein

HDL:

high density lipoprotein

IL:

interleukin

LPS:

lipopolysaccharide

MMP:

matrix metalloproteinase

NFkB:

nuclear factor kB

SAF1:

SAA-activating factor

TIMP:

tissue inhibitor of matrix metalloproteinase

TNF:

tumor necrosis factor

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Authors and Affiliations

  1. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, 119121, Moscow, Russia

    M. A. Vlasova & S. A. Moshkovskii

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  1. M. A. Vlasova
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  2. S. A. Moshkovskii
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Correspondence to S. A. Moshkovskii.

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Original Russian Text © M. A. Vlasova, S. A. Moshkovskii, 2006, published in Biokhimiya, 2006, Vol. 71, No. 10, pp. 1301–1311.

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Vlasova, M.A., Moshkovskii, S.A. Molecular interactions of acute phase serum amyloid A: Possible involvement in carcinogenesis. Biochemistry (Moscow) 71, 1051–1059 (2006). https://doi.org/10.1134/S0006297906100014

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