Abstract
The cerebellum is densely interconnected with sensory-motor areas of the cerebral cortex, and in man, the great expansion of the association areas of cerebral cortex is also paralleled by an expansion of the lateral cerebellar hemispheres. It is therefore likely that these circuits contribute to non-motor cognitive functions, but this is still a controversial issue. One approach is to examine evidence from neuropsychiatric disorders of cerebellar involvement. In this review, we narrow this search to test whether there is evidence of motor dysfunction associated with neuropsychiatrie disorders consistent with disruption of cerebellar motor function. While we do find such evidence, especially in autism, schizophrenia and dyslexia, we caution that the restricted set of motor symptoms does not suggest global cerebellar dysfunction. Moreover, these symptoms may also reflect involvement of other, extra-cerebellar circuits and detailed examination of specific sub groups of individuals within each disorder may help to relate such motor symptoms to cerebellar morphology.
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Allen G, Buxton RB, Wong EC. Attentional activation of the cerebellum independent of motor involvement. Science. 1997;275:1940–43.
Konarski JZ, Mclntyre RS, Grupp LA, Kennedy SH. Is the cerebellum relevant in the circuitry of neuropsychiatric disorders? J. Psychiatry Neurosci. 2005;30:178–86.
Leroi I, O’Hearn E, Marsh L, et al. Psychopathology in patients with degenerative cerebellar diseases: A comparison to Huntington’s disease. Am J Psychiatry. 2002;159: 1306–14.
Schmahmann JD. An emerging concept. The cerebellar contribution to higher function. Arch Neurol. 1991;48: 1178–87.
Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121(Pt 4):561–79.
Schmahmann JD. Disorders of the cerebellum: Ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci. 2004;16: 367–78.
Schmahmann JD. Rediscovery of an early concept. In: Schmahmann JD, editor. The cerebellum and cognition. San Diego: Academic Press; 1997. pp 3–27.
Ramnani N. The primate cortico-cerebellar system: Anatomy and function. Nat Rev Neurosci. 2006;7(7): 511–22.
Ramnani N, Behrens TE, Johansen-Berg H, et al. The evolution of prefrontal inputs to the cortico-pontine system: Diffusion imaging evidence from Macaque monkeys and humans. Cereb Cortex. 2006;16(6):811–8.
Akshoomoff NA, Courchesne E, Townsend J. Attention coordination and anticipatory control. Int Rev Neurobiol. 1997;41:575–98.
Moretti R, Bava A, Torre P, et al. Reading errors in patients with cerebellar vermis lesions. J Neurol. 2002;249:461–8.
Scott RB, Stoodley CJ, Anslow P, Paul C, Stein JF, et al. Lateralized cognitive deficits in children following cerebellar lesions. Dev Med Child Neurol. 2001;43:685–91.
Wassmer E, Davies P, Whitehouse WP, Green SH. Clinical spectrum associated with cerebellar hypoplasia. Pediatr Neurol. 2003;28:347–51.
Holmes G. The symptoms of acute cerebellar lesions due to gunshot injuries. Brain. 1917;40:461–535.
Holmes G. The cerebellum of man. Brain. 1939;62:l-30.
Eccles JC, Ito M, Szentagothai J. The cerebellum as a neuronal machine. New York: Springer; 1967.
Ito M. The cerebellum and neural control. New York: Raven Press; 1984.
Stein JF, Glickstein M. The role of the cerebellum in the visual guidance of movement. Physiol Rev. 1992;72: 967–1017.
Thach WT, Goodkin HP, Keating JG. The cerebellum and the adaptive coordination of movement. Ann Rev Neurosci. 1992;15:403–42.
Frith U. Autism and Asperger’s syndrome. Cambridge: Cambridge University Press; 1991.
Kanner L. Autistic disturbances of affective contact. Nervous Child. 1943;2:217–50.
Bauman ML. Motor dysfunction in autism. In: Joseph AB, Young RR, editors. Movement disorders in neurology and neuropsychiatry. Boston MA: Blackwell Scientific; 1992. pp 658–61.
Wing L. Asperger’s syndrome: A clinical account. Psychol Med. 1981;11:115–29.
Fawcett AJ, Nicolson RI. Performance of dyslexic children on cerebellar and cognitive tests. J Mot Behav. 1999;31: 68–78.
Nicolson RI, Fawcett AJ, Dean P. Developmental dyslexia: The cerebellar deficit hypothesis. Trends Neurosci. 2001;24:508–11.
Bombin I, Arangon C, Buchanan RW. Significance and meaning of neurological signs in schizophrenia: Two decades later. Schizophr Bull. 2005;31:962–77.
Kraepelin E. Dementia praecox and paraphrenia. Edinburgh, UK: E&S Livingstone; 1919.
Owens DG, Johnstone EC, Frith CD. Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics. Arch Gen Psychiatry. 1982;39:452–61.
Dichgans J, Diener HC. Clinical evidence for functional compartmentalization of the cerebellum. In: Bioedel JR, Dichgans J, Precht W, editors. Cerebellar functions. Berlin/ Heidelberg: Springer-Verlag; 1984. pp 126–47.
Bonnefoi-Kyriacou B, Legallet E, Lee RG, Trouche E. Spatio-temporal and kinematic analysis of pointing movements performed by cerebellar patients with limb ataxia. Exp Brain Res. 1998;119:460–6.
Miall RC, Christensen LO. The effect of rTMS over the cerebellum in normal human volunteers on peg-board movement performance. Neurosci Lett. 2004;371:185–9.
Miall RC, Reckess GZ, Imamizu H. The cerebellum coordinates eye and hand tracking movements. Nat Neurosci. 2001;4:638–44.
van Donkelaar P, Lee RG. Interactions between the eye and hand motor systems: Disruptions due to cerebellar dysfunction. J Neurophysiol. 1994;72:1674–85.
Johnson. DS, Montgomery EB. Chapter 44: Pathophysiology of cerebellar disorders. In: Watts R, Koller W, editors. Movement disorders: Neurological principles and practice. New York: McGraw-Hill; 1997. pp 587–610.
Ivry RB, Keele SW, Diener HC. Dissociation of the lateral and medial cerebellum in movement timing and movement execution. Exp Brain Res. 1988;73:167–80.
Ivry R, Keele SW. Timing functions of the cerebellum. J Cogn Neurosci. 1989;1:136–52.
Ivry RB, Spencer RM. The neural representation of time. Curr Opin Neurobiol. 2004;14:225–32.
Diener HC, Dichgans J, Guschlbauer B, Bacher M, Langenbach P. Disturbances of motor preparation in basal ganglia and cerebellar disorders. Prog Brain Res. 1989;80: 481–8.
Muller F, Dichgans J. Dyscoordination of pinch and lift forces during grasp in patients with cerebellar lesions. Exp Brain Res. 1994;101:485–92.
Nowak DA, Hermsdorfer J, Marquardt C, Fuchs HH. Grip and load force coupling during discrete vertical arm movements with a grasped object in cerebellar atrophy. Exp Brain Res. 2002;145:28–39.
Serrien DJ, Wiesendanger M. Role of the cerebellum in tuning anticipatory and reactive grip force responses. J Cogn Neurosci. 1999;11:672–81.
Theoret H, Haque J, Pascual-Leone A. Increased variability of paced finger tapping accuracy following repetitive magnetic stimulation of the cerebellum in humans. Neurosci Lett. 2001;306:29–32.
Dow RS,Moruzzi, editors. The physiology and pathology of the cerebellum. Minneapolis: University of Minnesota Press; 1958.
Grodd W, Hulsmann E, Lotze M, Wildgruber D, Erb M. Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopic organization. Hum Brain Mapp. 2001;13(2):55–73.
Manni E, Petrosini L. A century of cerebellar somatotopy: A debated representation. Nat Rev Neurosci. 2004;5(3): 241–9.
Bastian A, Thach W. Structure and function of the cerebellum. In: Manto M, Pandolfo M, editors. The cerebellum and its disorders. New York: Cambridge University Press; 2002. pp 49–68.
Schoch B, Dimitrova A, Gizewski ER, Timmann D. Functional localization in the human cerebellum based on voxelwise statistical analysis: A study of 90 patients. Neuroimage. 2006;30(1):36–51.
Dum RP, Strick PL. An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex. J Neurophysiol. 2003;89(1):634–9.
Bower JM. Control of sensory data acquisition. Int Rev Neurobiol. 1997;41:489–513.
Bower JM. Is the cerebellum sensory for motor’s sake, or motor for sensory’s sake: The view from the whiskers of a rat? Prog Brain Res. 1997;114:463–96.
Paulin MG. The role of the cerebellum in motor control and perception. Brain Behav Evol. 1993;41:39–50.
Paulin MG. Evolution of the cerebellum as a neuronal machine for Bayesian state estimation. J Neural Eng. 2005;2(3):S219–34.
Kawato M, Gomi H. A computational model of four regions of the cerebellum based on feedback-error-learning. Biol Cybern. 1992;68:95–103.
Kawato M, Kuroda T, Imamizu H, Nakano E, Miyauchi S, Yoshioka T. Internal forward models in the cerebellum: fMRI study on grip force and load force coupling. Prog Brain Res. 2003;142:171–88.
Miall RC, Weir DJ, Wolpert DM, Stein JF. Is the cerebellum a Smith Predictor? J Motor Behav. 1993;25:203–16.
Nixon PD. The role of the cerebellum in preparing responses to predictable sensory events. Cerebellum. 2003;2:114–22.
Henderson SE, Sugden D, editors. The movement assessment battery for children. London: The Psychological Corporation; 1992.
Bruininks RH, editor. The Bruininks-Oseretsky test of motor proficiency. Circle Pines, MN: American Guidance Service; 1978.
Buchanan RW, Heinrichs DW. The Neurological Evaluation Scale (NES): A structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res. 1989;27:335–50.
Stott DH, Moyes FA, Henerson SE. Manual: Test of motor impairment (Henderson revision). Guelph, Canada: Brook International; 1984.
Frith U. Emanuel Miller lecture: Confusions and controversies about Asperger syndrome. J Child Psychol Psychiatry. 2004;45:672–86.
Ghaziuddin M, Butler E, Tsai L, et al. Is clumsiness a marker for Asperger syndrome? J Intellect Disabil Res. 1994;38(Pt 5):519–27.
Manjiviona J, Prior M. Comparison of Asperger syndrome and high-functioning autistic children on a test of motor impairment. J Autism Dev Disord. 1995;25:23–39.
Ghaziuddin M, Butler E. Clumsiness in autism and Asperger syndrome: A further report. J Intellect Disabil Res. 1998;42(Pt 1):43–8.
Rinehart NJ, Bradshaw JL, Moss SA, et al. A deficit in shifting attention present in high-functioning autism but not Asperger’s disorder. Autism. 2001;5:67–80.
Nayate A, Bradshaw JL, Rinehart NJ. Autism and Asperger’s disorder: Are they movement disorders involving the cerebellum and/or basal ganglia? Brain Res Bull. 2005;67: 327–34.
Gillberg C. Asperger syndrome in 23 Swedish children. Dev Med Child Neurol. 1989;31:520–31.
Weimer AK, Schatz AM, Lincoln A, et al. “Motor” impairment in Asperger syndrome: Evidence for a deficit in proprioception. J Dev Behav Pediatr. 2001;22:92–101.
Green D, Baird G, Barnett AL, et al. The severity and nature of motor impairment in Asperger’s syndrome: A comparison with specific developmental disorder of motor function. J Child Psychol Psychiatry. 2002;43:655–68.
Miyahara M, Tsujii M, Hori M, et al. Brief report: Motor incoordination in children with Asperger syndrome and learning disabilities. J Autism Dev Disord. 1997;27: 595–603.
Gowen E, Miall RC. Behavioural aspects of cerebellar function in adults with Asperger syndrome. Cerebellum. 2005;4:279–89.
Schmitz C, Martineau J, Barthelemy C, et al. Motor control and children with autism: Deficit of anticipatory function? Neurosci Lett. 2003;348:17–20.
Miall RC, Imamizu H, Miyauchi S. Activation of the cerebellum in co-ordinated eye and hand tracking movements: An fMRI study. Exp Brain Res. 2000;135(1):22–33.
Hardan AY, Kilpatrick M, Keshavan MS, et al. Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autism. J Child Neurol. 2003;18:317–24.
Mari M, Castiello U, Marks D, et al. The reach-to-grasp movement in children with autism spectrum disorder. Philos Trans R Soc Lond B Biol Sci. 2003;358:393–403.
Ouchi Y, Okada H, Yoshikawa E, et al. Brain activation during maintenance of standing postures in humans. Brain. 1999;122(Pt 2):329–38.
Minshew NJ, Sung K, Jones BL, et al. Underdevelopment of the postural control system in autism. Neurology. 2004;63: 2056–61.
Diener HC, Dichgans J. Chapter 9: Cerebellar and spinocerebellar gait disorders. In: Bronstein A, Brandt T, Woollacott M, editors. Clinical disorders of balance, posture and gait. London, Sydney, Aukland: Arnold; 1996. pp 138–55.
Martineau J, Schmitz C, Assaiante C, et al. Impairment of a cortical event-related desynchronisation during a bimanual load-lifting task in children with autistic disorder. Neurosci Lett. 2004;367:298–303.
Flanagan JR, Wing AM. The role of internal models in motion planning and control: Evidence from grip force adjustments during movements of hand-held loads. J Neurosci. 1997;17:1519–28.
Johansson RS, Westling G. Roles of glabrous skin receptors and sensorimotor memory in automatic control of precision grip when lifting rougher or more slippery objects. Exp Brain Res. 1984;56:550–64.
Sears LL, Finn PR, Steinmetz JE. Abnormal classical eyeblink conditioning in autism. J Autism Dev Disord. 1994;24:737–51.
Steinmetz JE. Brain substrates of classical eyeblink conditioning: A highly localized but also distributed system. Behav Brain Res. 2000;110:13–24.
Mangels JA, Ivry RB, Shimizu N. Dissociable contributions of the prefrontal and neocerebellar cortex to time perception. Brain Res Cogn Brain Res. 1998;7:15–39.
Nichelli P, Alway D, Grafman J. Perceptual timing in cerebellar degeneration. Neuropsychologia. 1996;34: 863–71.
Woodruff-Pak D, Papka M, Ivry R. Cerebellar involvement in eyeblink classical conditioning in humans. Neuropsychology. 1996;10:443–58.
Bailey A, Luthert P, Dean A, et al. A clinicopathological study of autism. Brain. 1998;121(Pt 5):889–905.
Courchesne E. Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Curr Opin Neurobiol. 1997;7(2):269–78.
Abell F, Krams M, Ashburner J, et al. The neuroanatomy of autism: A voxel-based whole brain analysis of structural scans. Neuroreport. 1999;10:1647–51.
Murakami JW, Courchesne E, Press GA, et al. Reduced cerebellar hemisphere size and its relationship to vermal hypoplasia in autism. Arch Neurol. 1989;46: 689–94.
Ramnani N, Behrens TE, Johansen-Berg H, Richter MC, Pinsk MA, Andersson JL, et al. The evolution of prefrontal inputs to the cortico-pontine system: diffusion imaging evidence from Macaque monkeys and humans. Cereb Cortex. 2006;16(6):811–8.
Pierce K, Courchesne E. Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biol Psychiatry. 2001;49:655–64.
Allen G, Courchesne E. Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: An fMRI study of autism. Am J Psychiatry. 2003;160:262–73.
Allen G, Muller RA, Courchesne E. Cerebellar function in autism: Functional magnetic resonance image activation during a simple motor task. Biol Psychiatry. 2004;56: 269–78.
Muller RA, Kleinhans N, Kemmotsu N, et al. Abnormal variability and distribution of functional maps in autism: An FMRI study of visuomotor learning. Am J Psychiatry. 2003;160:1847–62.
Townsend J, Westerfield M, Leaver E, et al. Event-related brain response abnormalities in autism: Evidence for impaired cerebello-frontal spatial attention networks. Brain Res Cogn Brain Res. 2001;11:127–45.
Akshoomoff NA, Courchesne E. A new role for the cerebellum in cognitive operations. Behav Neurosci. 1992;106:731–8.
Ravizza SM, Ivry RB. Comparison of the basal ganglia and cerebellum in shifting attention. J Cogn Neurosci. 2001;13: 285–97.
Schoch B, Gorissen B, Richter S, et al. Do children with focal cerebellar lesions show deficits in shifting attention? J Neurophysiol. 2004;92:1856–66.
Bischoff-Grethe A, Ivry RB, Grafton ST. Cerebellar involvement in response reassignment rather than attention. J Neurosci. 2002;22:546–53.
Nicolson RI, Fawcett A.J, Dean P. Time estimation deficits in developmental dyslexia: evidence of cerebellar involvement. Proc Biol Sci. 1995;259:43–7.
Fawcett A.J, Nicolson RI, Dean P. Impaired performance of children with dyslexia on a range of cerebellar tasks. Ann Dyslexia. 1996;46:259–83.
Stoodley CJ, Fawcett A.J, Nicolson RI, Stein JF. Impaired balancing ability in dyslexic children. Exp Brain Res. 2005;167:370–80.
Stoodley CJ, Stein JF. A processing speed deficit in dyslexic adults? Evidence from a peg-moving task. Neurosci Lett. 2006;399:264–7.
Stoodley CJ, Harrison EP, Stein JF. Implicit motor learning deficits in dyslexic adults. Neuropsychologia. 2006;44: 795–8.
Eckert MA, Leonard CM, Richards TL, Aylward EH, Thomson J, Berninger VW. Anatomical correlates of dyslexia: Frontal and cerebellar findings. Brain. 2003;126(2):482–94.
Eckert MA. Neuroanatomical markers for dyslexia: A review of dyslexia structural imaging studies. Neuroscientist. 2004;10(4):362–71.
Eckert MA, Leonard CM, Wilke M, Eckert M, Richards T, Richards A, Berninger V. Anatomical signatures of dyslexia in children: Unique information from manual and voxel based morphometry brain measures. Cortex. 2005;41(3): 304–15.
Rae C, Harasty JA, Dzendrowskyj TE, et al. Cerebellar morphology in developmental dyslexia. Neuropsychologia. 2002;40:1285–92.
Nicolson RI, Fawcett AJ, Berry EL, et al. Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet. 1999;353:1662–7.
Ramus F, Pidgeon E, Frith U. The relationship between motor control and phonology in dyslexic children. J Child Psychol Psychiatry. 2003;44(5):712–22.
Akshoomoff NA, Courchesne E, Press GA, Iragui V. Contribution of the cerebellum to neuropsychological functioning: Evidence from a case of cerebellar degenerative disorder. Neuropsychologia. 1992;30:315–28.
Snider SR. Cerebellar pathology in schizophrenia-cause or consequence? Neurosci Behave Rev. 1982;6:47–53.
Andreasen NC, O’Leary DS, Cizadlo T, et al. Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc Natl Acad Sci USA. 1996;93: 9985–90.
Andreasen NC, Nopoulos P, O’Leary DS, Miller DD, Wassink T, Flaum M. Defining the phenotype of schizophrenia: Cognitive dysmetria and its neural mechanisms. Biol Psychiatry. 1999;46:908–20.
Schmahmann JD. The role of the cerebellum in affect and psychosis. J Neurolinguistics. 2000;13:189–214.
Bachmann S, Bottmer C, Schroder J. Neurological soft signs in first-episode schizophrenia: A follow-up study. Am J Psychiatry. 2005;162:2337–43.
Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology. 1998;12:426–45.
Keshavan MS, Sanders RD, Sweeney JA, et al. Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses. Am J Psychiatry. 2003;160:1298–304.
Quitkin F, Rifkin A, Klein D. Neurological signs in schizophrenia and character disorders. Arch Gen Psychiat. 1976;33:845–53.
Schroder J, Niethammer R, Geider FJ, et al. Neurological soft signs in schizophrenia. Schizophr Res. 1991;6:25–30.
Venkatasubramanian G, Latha V, Gangadhar BN, et al. Neurological soft signs in never-treated schizophrenia. Acta Psychiatr Scand. 2003;108:144–6.
Dazzan P, Murray RM. Neurological soft signs in first-episode psychosis: A systematic review. Br J Psychiatry Suppl. 2002;43:s50–7.
Boks MP, Liddle PF, Burgerhof JG, et al. Neurological soft signs discriminating mood disorders from first episode schizophrenia. Acta Psychiatr Scand. 2004;110:29–35.
Lehoux C, Everett J, Laplante L, et al. Fine motor dexterity is correlated to social functioning in schizophrenia. Schizophr Res. 2003;62:269–73.
Sullivan EV, Fama R, Shear PK, et al. Motor sequencing deficits in schizophrenia: A comparison with Parkinson’s disease. Neuropsychology. 2001;15:342–50.
Nopoulos PC, Ceilley JW, Gailis EA, Andreasen NC. An MRI study of cerebellar vermis morphology in patients with schizophrenia: Evidence in support of the cognitive dysmetria concept. Biol Psychiatry. 1999;46:703–11.
Wassink TH, Andreasen NC, Nopoulos P, Flaum M. Cerebellar morphology as a predictor of symptom and psychosocial outcome in schizophrenia. Biol Psychiatry. 1999;45:41–8.
Frith CD, Blakemore S, Wolpert DM. Explaining the symptoms of schizophrenia: Abnormalities in the awareness of action. Brain Res Brain Res Rev. 2000;31:357–63.
Haggard P, Martin F, Taylor-Clarke M, Jeannerod M, Franck N. Awareness of action in schizophrenia. Neuroreport. 2003;14:1081–5.
Lindner A, Their P, Kircher TT, Haarmeier T, Leube DT. Disorders of agency in schizophrenia correlate with an inability to compensate for the sensory consequences of actions. Curr Biol. 2005;15:1119–24.
Shergill SS, Samson G, Bays PM, Frith CD, Wolpert DM. Evidence for sensory prediction deficits in schizophrenia. Am J Psychiatry. 2005;162:2384–6.
Blakemore SJ, Wolpert D, Frith C. Why can’t you tickle yourself? Neuroreport. 2000;11:R11-R6.
Franck N, Farrer C, Georgieff N, et al. Defective recognition of one’s own actions in patients with schizophrenia. Am J Psychiatry. 2001;158:454–9.
Delevoye-Turrell Y, Giersch A, Danion H. Abnormal sequencing of motor actions in patients with schizophrenia: Evidence from grip force adjustments during object manipulation. Am J Psychiatry. 2003;160:134–41.
Franck N, Posada A, Pichon S, et al. Altered subjective time of events in schizophrenia. J Nerv Ment Dis. 2005;193: 350–3.
Elvevag B, McCormack T, Gilbert A, Brown GD, Weinberger DR, Goldberg TE. Duration judgements in patients with schizophrenia. Psychol Med. 2003;33: 1249–61.
Ho BC, Mola C, Andreasen NC. Cerebellar dysfunction in neuroleptic naive schizophrenia patients: Clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs. Biol Psychiatry. 2004;55:1146–53.
Kinney DK, Yurgelun-Todd DA, Woods BT. Neurologic signs of cerebellar and cortical sensory dysfunction in schizophrenics and their relatives. Schizophr Res. 1999;35: 99–104.
Marvel CL, Schwartz BL, Rosse RB. A quantitative measure of postural sway deficits in schizophrenia. Schizophr Res. 2004;68:363–72.
Deshmukh A, Rosenbloom MJ, Pfefferbaum A, Sullivan EV. Clinical signs of cerebellar dysfunction in schizophrenia, alcoholism, and their comorbidity. Schizophr Res. 2002;57:281–91.
Fadda F, Rossetti ZL. Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Prog Neurobiol. 1998;56(4):385–431.
Kumari V, Gray JA, Honey GD, Soni W, Bullmore ET, Williams SC, Ng VW, Vythelingum GN, Simmons A, Suckling J, Corr PJ, Sharma T. Procedural learning in schizophrenia: A functional magnetic resonance imaging investigation. Schizophr Res. 2002;57(1):97–107.
Farrer C, Franck N, Frith CD, Decety J, Georgieff N, d’Amato T, Jeannerod M. Neural correlates of action attribution in schizophrenia. Psychiatry Res. 2004;131(1): 31–44.
Spence SA, Brooks DJ, Hirsch SR, Liddle PF, Meehan J, Grasby PM. A PET study of voluntary movement in schizophrenic patients experiencing passivity phenomena (delusions of alien control). Brain. 1997;120(11): 1997–2011.
Beyer JL, Krishnan KR. Volumetric brain imaging findings in mood disorders. Bipolar Disord. 2002;4:89–104.
Strakowski SM, DelBello MP, Adler CM. The functional neuroanatomy of bipolar disorder: A review of neuroimaging findings. Mol Psychiatry. 2005;10:105–16.
DelBello MP, Strakowski SM, Zimmerman ME, Hawkins JM, Sax KW. MRI analysis of the cerebellum in bipolar disorder: A pilot study. Neuropsychopharmacology. 1999;21(1):63–8.
Cecil KM, DelBello MP, Scilars MC, Strakowski SM. Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. J Child Adolesc Psychopharmacol. 2003;13(4):545–55.
Ketter TA, Kimbrell TA, George MS, Dunn RT, Speer AM, Benson BE, Willis MW, Danielson A, Frye MA, Herscovitch P, Post RM. Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biol Psychiatry. 2001;49(2):97–109.
Dickstein DP, Garvey M, Pradella AG, et al. Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;58:517–24.
Negash A, Kebede D, Alem A, et al. Neurological soft signs in bipolar I disorder patients. J Affect Disord. 2004;80: 221–30.
Maj M. The effect of lithium in bipolar disorder: A review of recent research evidence. Bipolar Disord. 2003;5:180–8.
Silverstone PH, Silverstone T. A review of acute treatments for bipolar depression. Int Clin Psychopharmacol. 2004;19:113–24.
Adityanjee, Munshi KR, Thampy A. The syndrome of irreversible lithium-effectuated neurotoxicity. Clin Neuropharmacol. 2005;28:38–49.
Mills NP, DelBello MP, Adler CM, et al. MRI analysis of cerebellar vermal abnormalities in bipolar disorder. Am J Psychiatry. 2005;162:1530–2.
Loeber RT, Gruber SA, Cohen BM, et al. Cerebellar blood volume in bipolar patients correlates with medication. Biol Psychiatry. 2002;51:370–6.
Schneider M, Retz W, Coogan A, et al. Anatomical and functional brain imaging in adult attention-deficit/hyperactivity disorder (ADHD)-A neurological view. Eur Arch Psychiatry Clin Neurosci. 2006;256(Suppl. 1):i32–41.
Carmon S, Vilarroya O, Bielsa A, Tremols V, et al. Global and regional gray matter reductions in ADHD: A voxel-based morphometric study. Neurosci Lett. 2005;389(2): 88–93.
Berquin PC, Giedd JN, Jacobsen LK, Hamburger SD, et al. Cerebellum in attention-deficit hyperactivity disorder: A morphometric MRI study. Neurology. 1998;50(4):1087–93.
Dickstein SG, Bannon K, Xavier Castellanos F, Milham MP. The neural correlates of attention deficit hyperactivity disorder: An ALE meta-analysis. J Child Psychol Psychiatry. 2006;47(10):1051–62.
Dickstein DP, Garvey M, Pradella AG, et al. Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;58:517–24.
Karatekin C, Markiewicz SW, Siegel MA. A preliminary study of motor problems in children with attention-deficit/ hyperactivity disorder. Percept Mot Skills. 2003;97: 1267–80.
Piek JP, Skinner RA. Timing and force control during a sequential tapping task in children with and without motor coordination problems. J Int Neuropsychol Soc. 1999;5: 320–9.
Piek JP, Pitcher TM, Hay DA. Motor coordination and kinaesthesis in boys with attention deficit-hyperactivity disorder. Dev Med Child Neurol. 1999;41:159–65.
Raberger T, Wimmer H. On the automaticity/cerebellar deficit hypothesis of dyslexia: Balancing and continuous rapid naming in dyslexic and ADHD children. Neuropsychologia. 2003;41:1493–7.
Toplak M, Dockstader C, Tannock R. Temporal information processing in ADHD: Findings to date and new methods. J Neurosci Methods. 2006;151:15–29.
Radonovich KJ, Mostofsky SH. Duration judgments in children with ADHD suggest deficient utilization of temporal information rather than general impairment in timing. Child Neuropsychol. 2004;10:162–72.
Lewis PA, Miall RC. Distinct systems for automatic and cognitively controlled time measurement: Evidence from neuroimaging. Curr Opin Neurobiol. 2003;13: 250–5.
Piek JP, Dyck MJ. Sensory-motor deficits in children with developmental coordination disorder, attention deficit hyperactivity disorder and autistic disorder. Hum Mov Sci. 2004;23:475–88.
van Meel CS, Oosterlaan J, Heslenfeld DJ, et al. Motivational effects on motor timing in attention-deficit/ hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2005;44:451–60.
Shaw G, Brown G. Arousal, time estimation and time use in attentional-disordered children. Develop Neuropsychol. 1999;16:227–42.
Pitcher TM, Piek JP, Hay DA. Fine and gross motor ability in males with ADHD. Dev Med Child Neurol. 2003;45:525–35.
Gillberg C, Kadesjo B. Why bother about clumsiness? The implications of having developmental coordination disorder (DCD). Neural Plast. 2003;10:59–68.
Castellanos FX, Sonuga-Barke EJ, Milham MP, et al. Characterizing cognition in ADHD: Beyond executive dysfunction. Trends Cogn Sci. 2006;10:117–23.
Sullivan EV, Deshmukh A, Desmond JE, et al. Cerebellar volume decline in normal aging, alcoholism, and Korsakoff s syndrome: Relation to ataxia. Neuropsychology. 2000;14: 341–52.
Jancke L, Loose R, Lutz K, Specht K, Shah NJ. Cortical activations during paced finger-tapping applying visual and auditory pacing stimuli. Brain Res Cogn Brain Res. 2000;(10):51–66.
Rao SM, Harrington DL, Haaland KY, Bobholz JA, Cox RW, Binder JR. Distributed neural systems underlying the timing of movements. J Neurosci. 1997;17: 5528–35.
Jueptner M, Flerich L, Weiller C, et al. The human cerebellum and temporal information processing — results from a PET experiment. Neuroreport. 1996;7:2761–5.
Penhune VB, Zattore RJ, Evans AC. Cerebellar contributions to motor timing: A PET study of auditory and visual rhythm reproduction. J Cogn Neurosci. 1998;10: 752–65.
Coffin JM, Baroody S, Schneider K, et al. Impaired cerebellar learning in children with prenatal alcohol exposure: A comparative study of eyeblink conditioning in children with ADHD and dyslexia. Cortex. 2005;41: 389–98.
Nicolson RI, Daum I, Schugens MM, et al. Eyeblink conditioning indicates cerebellar abnormality in dyslexia. Exp Brain Res. 2002;143:42–50.
Blakemore SJ, Tavassoli T, Calo S, et al. Tactile sensitivity in Asperger syndrome. Brain Cogn. 2006;61:5–13.
O’Riordan MA, Plaisted KC, Driver J, et al. Superior visual search in autism. J Exp Psychol Hum Percept Perform. 2001;27:719–30.
Mottron L, Dawson M, Soulieres I, et al. Enhanced perceptual functioning in autism: An update, and eight principles of autistic perception. J Autism Dev Disord. 2006;36:27–43.
Bertone A, Mottron L, Jelenic P, et al. Motion perception in autism: A “complex” issue. J Cogn Neurosci. 2003;15: 218–25.
Pellicano E, Gibson L, Maybery M, et al. Abnormal global processing along the dorsal visual pathway in autism: A possible mechanism for weak visuospatial coherence? Neuropsychologia. 2005;43:1044–53.
Dakin S, Carlin P, Hemsley D. Weak suppression of visual context in chronic schizophrenia. Curr Biol. 2005;15: R822–4.
Dakin S, Frith U. Vagaries of visual perception in autism. Neuron. 2005;48:497–507.
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Gowen, E., Miall, R.C. The cerebellum and motor dysfunction in neuropsychiatric disorders. Cerebellum 6, 268–279 (2007). https://doi.org/10.1080/14734220601184821
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DOI: https://doi.org/10.1080/14734220601184821