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Valproic acid does not affect markers of human immunodeficiency virus disease progression

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Abstract

Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells. This retrospective case-control study (n = 30) examined effects of VPA on markers of HIV progression. VPA was not associated with changes in cerebrospinal fluid viral loads (VL), plasma VL, or neuropsychological performance. VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention.

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References

  • Acharya S, Bussel JB (2000). Hematologic toxicity of sodium valproate. J Pediatr Hematol Oncol 22: 62–65.

    Article  CAS  PubMed  Google Scholar 

  • Carey CL, Woods SP, Rippeth JD, Gonzalez R, Moore DJ, Marcotte TD, Grant I, Heaton RK, Group H (2004). Initial validation of a screening battery for the detection of HIV-associated cognitive impairment. Clini Neuropsychol 18: 234–248.

    Article  Google Scholar 

  • Heaton RK, Marcotte TD, Mindt MR, Sadek J, Moore DJ, Bentley H, McCutchan JA, Reicks C, Grant I, Group H (2004). The impact of HIV-associated neuropsychological impairment on everyday functioning. J Int Neuropsychol Soc 10: 317–331.

    Article  PubMed  Google Scholar 

  • Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM (2005). Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366: 549–555.

    Article  CAS  PubMed  Google Scholar 

  • Robinson B, Turchan J, Anderson C, Chauhan A, Nath A (2006). Modulation of human immunodeficiency virus infection by anticonvulsant drugs. J NeuroVirol 12: 1–4.

    Article  CAS  PubMed  Google Scholar 

  • Schifitto G, Peterson DR, Zhong J, Ni H, Cruttenden K, Gaugh M, Gendelman HE, Boska M, Gelbard H (2006). Valproic acid adjunctive therapy for HIV-associated cognitive impairment. A first report. Neurology 66: 919–921.

    Article  CAS  PubMed  Google Scholar 

  • Smith SM (2005). Valproic acid and HIV-1 latency: beyond the sound bite. Retrovirology 2: 56.

    Article  PubMed  Google Scholar 

  • Ylisastigui L, Archin NM, Lehrman G, Bosch RJ, Margolis DM (2004). Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression. AIDS 18: 1101–1108.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosciences, University of California, San Diego, California, USA

    Beau M. Ances, Maria Buzzell, Jennifer Marquie-Beck, Deborah Lazaretto & Ronald J. Ellis

  2. Department of Medicine, University of California, San Diego, California, USA

    Scott Letendre

  3. Department of Psychiatry, University of California, San Diego, California, USA

    Thomas D. Marcotte & Igor Grant

  4. HIV Neurobehavioral Research Center, 150 W. Washington, 2nd Floor, 92119, San Diego, CA, USA

    Beau M. Ances

Authors
  1. Beau M. Ances
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  2. Scott Letendre
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  3. Maria Buzzell
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  4. Jennifer Marquie-Beck
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  5. Deborah Lazaretto
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  6. Thomas D. Marcotte
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  7. Igor Grant
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  8. Ronald J. Ellis
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HNRC Group

Corresponding author

Correspondence to Beau M. Ances.

Additional information

The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government.

This work was supported by University of California Universitywide AIDS Research Program Fellowship (CF05-SD-301; B.A.) and amFAR Fellowship (106729-40-RFRL; B.A.). The HIV Neurobehavioral Research Center (HNRC) is supported by Center award MH 62512 from the National Institute of Mental Health (HIV Neurobehavioral Research Center, S.L., T.M., I.G., R.E).

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Ances, B.M., Letendre, S., Buzzell, M. et al. Valproic acid does not affect markers of human immunodeficiency virus disease progression. Journal of NeuroVirology 12, 403–406 (2006). https://doi.org/10.1080/13550280600981695

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  • DOI: https://doi.org/10.1080/13550280600981695

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