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Determining variables for repeat prostate biopsy

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Abstract

During the evaluation of prostate cancer, men who have undergone transrectal ultrasound-guided biopsy with negative results present a dilemma as to what further follow-up is required. Multiple variables have been proposed throughout the literature to improve cancer detection rates not only in initial biopsy results, but also on repeat evaluation. These variables include prostate-specific antigen (PSA) velocity, PSA density, free-percent PSA, and histological findings, each of which may singly or collectively dictate the need for further biopsy. After performing a Medline literature search using specific Medical Subject Headings (prostate biopsy, repeat prostate biopsy, PSA velocity, PSA density, free-percent PSA, prostate inflammation), we critically evaluated pertinent articles. Using this accumulated data and information, we composed an algorithm to assist in the decision process for repeat biopsy.

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Authors and Affiliations

  1. Department of Urology, University of California, Davis, Sacramento, California, USA

    J E Busby & C P Evans

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  1. J E Busby
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  2. C P Evans
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Correspondence to C P Evans.

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Busby, J., Evans, C. Determining variables for repeat prostate biopsy. Prostate Cancer Prostatic Dis 7, 93–98 (2004). https://doi.org/10.1038/sj.pcan.4500708

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  • DOI: https://doi.org/10.1038/sj.pcan.4500708

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