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β-Catenin regulates the expression of tenascin-C in human colorectal tumors

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Abstract

Tenascin-C (TN-C) is a component of the extracellular matrix (ECM). It is expressed during development and re-expressed in many types of cancers, where it is involved in the modulation of adhesion and proliferation. TN-C expression is especially high at sites of epithelial mesenchymal transition (EMT), which are found frequently at the invasion front of well-differentiated human colorectal adenocarcinomas. Tumor cells in this compartment are characterized by a strong nuclear expression of the oncogenic transcription factor β-catenin. Here, we demonstrate that TN-C is a β-catenin target gene in human colorectal tumors. Thus, by far the most common mutations in colorectal tumors, found in the Wnt-signaling pathway and leading to the stabilizing of β-catenin, might influence invasion by altering adhesive properties and EMT of tumor cells.

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Acknowledgements

This work was supported by the Wilhelm Sander-Stiftung (Az.: 1999.065.2). We thank Professor Amann for kindly providing her digital photosystem.

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  1. Katharina Beiter

    Present address: Swedish Institute for Infectious Disease Control, S-17182, Solna, Sweden

Authors and Affiliations

  1. Pathologisch-Anatomisches Institut, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstr, 8-10, D-91054, Erlangen, Germany

    Katharina Beiter, Elke Hiendlmeyer, Thomas Brabletz, Falk Hlubek, Angela Haynl, Claudia Knoll, Thomas Kirchner & Andreas Jung

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  1. Katharina Beiter
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  2. Elke Hiendlmeyer
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  3. Thomas Brabletz
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  5. Angela Haynl
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  6. Claudia Knoll
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  7. Thomas Kirchner
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  8. Andreas Jung
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Correspondence to Andreas Jung.

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Beiter, K., Hiendlmeyer, E., Brabletz, T. et al. β-Catenin regulates the expression of tenascin-C in human colorectal tumors. Oncogene 24, 8200–8204 (2005). https://doi.org/10.1038/sj.onc.1208960

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  • DOI: https://doi.org/10.1038/sj.onc.1208960

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