Abstract
The v-Myb oncogene causes late onset T cell lymphomas when expressed in the T cell lineage of transgenic mice. In order to define the cellular mutations cooperating with v-Myb to cause lymphomas, we have infected v-Myb transgenic mice with Moloney murine leukemia virus (M-MuLV). Tumor formation is significantly accelerated from a mean age of onset of 60 weeks in uninfected vMyb transgenics to 13 weeks in infected vMyb transgenics. We studied the loci into which the M-MuLV had inserted, and found that in 73% of animals, either the c-myc or the N-myc genes had been disrupted and deregulated. Therefore, v-myb and c-myb can cooperate to induce T cell lymphomas.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alitalo K, Winqvist R, Lin CC, de la Chapelle A, Schwab M and Bishop JM . 1984 Proc. Natl. Acad. Sci. USA 81: 4534–4538.
Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA and Struhl K. (eds) . 1987 Current Protocols in Molecular Biology. John Wiley and Sons, Inc., New York.
Badiani P, Kioussis D, Swirsky D, Lampert I and Weston K. . 1996 Oncogene 13: 2205–2212.
Calabretta B, Sims RB, Valtieri M, Caracciolo D, Szczylik C, Venturelli D, Ratajczak M, Beran M and Gewirtz AM. . 1991 Proc. Natl. Acad. Sci. USA 88: 2351–2355.
Furuta Y, Aizawa S, Suda Y, Ikawa Y, Nakasgoshi H, Nishina Y and Ishii S. . 1993 Transgenic Res. 2: 199–207.
Gisselbrecht S, Pozo F, Debre P, Hurot MA, Lacombe MJ and Levy JP. . 1978 Int. J. Cancer 21: 626–634.
Gonda TJ, Ramsay RG and Johnson GR. . 1989 EMBO J. 8: 1767–1775.
Hartley JW, Yetter RA and Morse III HC. . 1983 J. Exp. Med. 158: 16–24.
Jacobs SM, Gorse KM, Kennedy SJ and Westin EH. . 1994 Cancer Genet. Cytogenet. 75: 31–39.
Jaenisch R, Fan H and Croker B. . 1975 Proc. Natl. Acad. Sci. USA 72: 4008–4012.
Jiang X, Villeneuve L, Turmel C, Kozak CA and Jolicoeur P. . 1994 Mamm. Genome. 5: 142–148.
Jonkers J and Berns A. . 1996 Biochima et Biophysica Acta 1287: 29–57.
Kung HJ, Boerkoel C and Carter TH. . 1991 Curr. Top. Microbiol. Immunol. 171: 1–25.
Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN and Ness SA. . 1998 Mol. Cell. 2: 417–425.
Linette GP, Hess JL, Sentman CL and Korsmeyer SJ. . 1995 Blood 86: 1255–1260.
Mushinski JF, Potter M, Bauer SR and Reddy EP. . 1983 Science 220: 795–798.
Pelicci P-G, Lanfrancone L, Brathwaite MD, Wolman SR and Dalla-Favera R. . 1984 Science 224: 1117–1121.
Sanchez-Garcia I. . 1997 Annu. Rev. Genet. 31: 429–453.
Shinto Y, Morimoto M, Katsumata M, Uchida A, Aozasa K, Okamoto M, Kurosawa T, Ochi T, Greene MI and Tsujimoto Y. . 1995 Oncogene 11: 1729–1736.
Strasser A, Harris AW and Cory S. . 1991 Cell 67: 889–899.
Taylor D, Badiani P and Weston K. . 1996 Genes Dev. 10: 2732–2744.
van Lohuizen M and Berns A. . 1990 Biochim. Biophys. Acta. 1032: 213–235.
van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T and Berns A. . 1989 Cell 56: 673–682.
van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H and Berns A. . 1991 Cell 65: 737–752.
Vaux DL, Cory S and Adams JM. . 1988 Nature 335: 440–442.
Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P. . 1993 J. Virol. 67: 5733–5739.
Weston K. . 1998 Curr. Opin. Genet. Dev. 8: 76–81.
Wolff L. . 1996 Crit. Rev. Oncogenesis 7: 245–260.
Acknowledgements
We thank Fred Alt (pN1.1; N-myc cDNA), Gerard Evan (pSV2mycS; c-myc cDNA) and Blanca Scheijen (pim-1 and gfi-1 genomic probes) for gifts of plasmids, and Jos Jonkers and Anton Berns for M-MuLV clone 1A cells and Eμpim-1 mice. This work was funded by the Cancer Research Campaign.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Davies, J., Badiani, P. & Weston, K. Cooperation of Myb and Myc proteins in T cell lymphomagenesis. Oncogene 18, 3643–3647 (1999). https://doi.org/10.1038/sj.onc.1202956
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1202956
- Springer Nature Limited
Keywords
This article is cited by
-
RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene
Oncogene (2013)
-
Functional annotation of novel lineage-specific genes using co-expression and promoter analysis
BMC Genomics (2010)
-
Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma
Leukemia (2004)
-
What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas
Leukemia (2002)
-
Expression of hpttg proto-oncogene in lymphoid neoplasias
Oncogene (2002)