Skip to main content

Advertisement

SpringerLink
Log in

DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases

  • Original Paper
  • Published:
Oncogene Submit manuscript

Abstract

Gestational trophoblastic diseases comprise a spectrum of interrelated diseases including partial mole, complete mole and gestational choriocarcinoma. Using reverse transcriptase PCR (RT–PCR) analysis, we identified higher levels of DOC-2/hDab2 expression in the normal trophoblast cells in culture than in choriocarcinoma cell lines. Subsequent study using immunohistochemistry showed high levels of DOC-2/hDab2 protein expression in normal trophoblast tissues but significantly lower levels of expression in gestational trophoblastic disease tissues, particularly in complete mole and choriocarcinoma. When DOC-2/hDab2 was transfected into the choriocarcinoma cell lines, Jar, JEG and BeWo, the stable transfectants showed significantly reduced growth rate in culture. These data suggest that down regulation of DOC-2/hDab2 may play an important role in the development of gestational trophoblastic diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Division of Gynecologic Oncology, Department of Obstetrics, Laboratory of Gynecologic Oncology, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Cristiano V Colitti, David Genest, Ross S Berkowitz, Gary K Yiu, Shu-wing Ng & Samuel C Mok

  2. Department of Obstetrics and Gynecology, Haynal Imre University for Health Sciences, Budapest, Hungary

    Vilmos Fulop & Janos Szepesi

Authors
  1. Vilmos Fulop
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cristiano V Colitti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Genest
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ross S Berkowitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gary K Yiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shu-wing Ng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Janos Szepesi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Samuel C Mok
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fulop, V., Colitti, C., Genest, D. et al. DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases. Oncogene 17, 419–424 (1998). https://doi.org/10.1038/sj.onc.1201955

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1201955

  • Springer Nature Limited

Keywords

This article is cited by

Search

Navigation