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LIS1—no more no less

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Abstract

LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly (‘smooth brain’). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the brain developmental phenotype observed in mice heterozygote for an N-terminal truncated LIS1 protein in view of known LIS1 protein interactions.

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Acknowledgements

Supported in Part by Fritz Thyssen Stiftung Foundation, BSF grant No. 97–00014, HFSP grant No. RG283199 9, Volkswagen-Stiftung, the Israeli Science Foundation grant No. 19/00, and Minerva Foundation, to OR, and by DGSYC project PM 98–0056, Foundation Seneca of Murcia: project 00708-CV-99 and CE Contracts QLG2-CT-99–793, QLG3–00–01625 to SM. OR is an Incumbent of Aser Rothstein Career Development Chair in Genetic Diseases.

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Authors and Affiliations

  1. Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel

    O Reiner & A Cahana

  2. Instituto de Neutociencias CSIC-UMH, Campus de San Juan, San Juan de Alicante, Spain

    T Escamez & S Martinez

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  1. O Reiner
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  2. A Cahana
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  3. T Escamez
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  4. S Martinez
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Correspondence to O Reiner.

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Reiner, O., Cahana, A., Escamez, T. et al. LIS1—no more no less. Mol Psychiatry 7, 12–16 (2002). https://doi.org/10.1038/sj.mp.4000975

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