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Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes

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Abstract

Presenilin-1 (PS1) deficiency in neurons derived from knockout mice results in a marked reduction in the production of amyloid peptide βA4 and an accumulation of carboxyterminal fragments of the amyloid precursor protein (APP).

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Authors and Affiliations

  1. Abteilung Biochemie II, Zentrum Biochemie und Molekulare Zellbiologie, Universität Göttingen, Germany

    P Saftig

  2. Center for Human Genetics,

    B de Strooper

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  1. P Saftig
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  2. B de Strooper
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Correspondence to P Saftig.

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Saftig, P., de Strooper, B. Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes. Mol Psychiatry 3, 287–289 (1998). https://doi.org/10.1038/sj.mp.4000408

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