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Vλ genes in chronic lymphocytic leukaemia: highly skewed V gene segment usage with similar CDR3 sequences

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References

  1. Duke VM, Gandini D, Sherrington PD, Lin K, Heelan B, Amlot P et al. V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia. Haematologica 2003; 88: 1259–1271.

    CAS  PubMed  Google Scholar 

  2. Matthews C, Catherwood MA, Morris TC, Alexander HD . V(H)3-48 and V(H)3-53, as well as V(H)3-21, gene rearrangements define unique subgroups in CLL and are associated with biased lambda light chain restriction, homologous LCDR3 sequences and poor prognosis. Leuk Res 2007; 31: 231–234.

    Article  CAS  Google Scholar 

  3. Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, Willander K et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104: 2879–2885.

    Article  CAS  Google Scholar 

  4. Widhopf II GF, Rassenti LZ, Toy TL, Gribben JG, Wierda WG, Kipps TJ . Chronic lymphocytic leukemia B-cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004; 104: 2499–2504.

    Article  Google Scholar 

  5. Widhopf II GF, Goldberg CJ, Toy TL, Rassenti LZ, Wierda WG, Byrd JC et al. Non-stochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B-cells is predicated on the heavy chain CDR3. Blood 2007 [E-pub ahead of print].

  6. Stamatopoulos K, Belessi C, Hadzidimitriou A, Smilevska T, Kalagiakou E, Hatzi K et al. Immunoglobulin light chain repertoire in chronic lymphocytic leukemia. Blood 2005; 106: 3575–3583.

    Article  CAS  Google Scholar 

  7. Giudicelli V, Duroux P, Ginestoux C, Folch G, Jabado-Michaloud J, Chaume D et al. IMGT/LIGM-DB, the IMGT comprehensive database of immunoglobulin and T-cell receptor nucleotide sequences. Nucleic Acids Res 2006; 34 (Database issue): D781–D784.

    Article  CAS  Google Scholar 

  8. Messmer BT, Albesiano E, Efremov DG, Ghiotto F, Allen SL, Kolitz J et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004; 200: 519–525.

    Article  CAS  Google Scholar 

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  1. A Abusedra and R Joshi: These authors contributed equally to this work.

Authors and Affiliations

  1. Division of Investigative Sciences, Department of Haematology, Hammersmith Hospital, London, UK

    A Abusedra, R Joshi, A Bybee, J F Apperley & S D Wagner

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  1. A Abusedra
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  2. R Joshi
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  3. A Bybee
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  4. J F Apperley
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  5. S D Wagner
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Correspondence to S D Wagner.

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Abusedra, A., Joshi, R., Bybee, A. et al. Vλ genes in chronic lymphocytic leukaemia: highly skewed V gene segment usage with similar CDR3 sequences. Leukemia 22, 1073–1075 (2008). https://doi.org/10.1038/sj.leu.2405003

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  • DOI: https://doi.org/10.1038/sj.leu.2405003

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