References
Royer-Pokora B, Loos U, Ludwig WD . TTG-2 a new gene encoding a cysteine-rich protein with LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 1991; 6: 1887–1893.
Yamada Y, Warren AJ, Dobson C, Forster A, Pannell R, Rabbitts TH . The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci USA 1998; 95: 3890–3895.
Yamada Y, Pannell R, Forster A, Rabbitts TH . The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci USA 2000; 97: 320–324.
Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 1997; 16: 3145–3157.
Shivdasani RA . MicroRNAs: regulators of gene expression and cell differentiation. Blood 2006; 108: 3646–3653.
Fazi F, Rosa A, Fatica A, Gelmetti V, Marchis MLD, Nervi C et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 2005; 123: 819–831.
Fukao T, Fukuda Y, Kiga K, Sharif J, Hino K, Enomoto Y et al. An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 2007; 129: 617–631.
Nam CH, Rabbitts TH . The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion. Mol Ther 2006; 13: 15–25.
Acknowledgements
This work was supported by the National Nature Science Foundation of China (No.30771054).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yuan, W., Sun, W., Yang, S. et al. Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors. Leukemia 22, 1067–1071 (2008). https://doi.org/10.1038/sj.leu.2405001
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2405001
- Springer Nature Limited
This article is cited by
-
miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates
Cell Research (2013)
-
Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes
Journal of Biomedical Science (2010)
-
miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β
Cell Research (2010)