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Translocation t(4;14) retains prognostic significance even in the setting of high-risk molecular signature

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A Corrigendum to this article was published on 13 February 2008

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References

  1. Avet-Loiseau H, Attal M, Moreau P, Charbonnel C, Garban F, Hulin C et al. Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome. Blood 2007; 109: 3489–3495.

    Article  CAS  Google Scholar 

  2. Shaughnessy Jr JD, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I et al. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood 2006; 109: 2276–2284.

    Article  Google Scholar 

  3. Chng WJ, Kumar S, Vanwier S, Ahmann G, Price-Troska T, Henderson K et al. Molecular dissection of hyperdiploid multiple myeloma by gene expression profiling. Cancer Res 2007; 67: 2982–2989.

    Article  CAS  Google Scholar 

  4. Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S et al. The molecular classification of multiple myeloma. Blood 2006; 108: 2020–2028.

    Article  CAS  Google Scholar 

  5. Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy Jr J . Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 2005; 106: 296–303.

    Article  CAS  Google Scholar 

  6. Xiong W, Zhan F, Huang Y, Barlogie B, Shaughnessy Jr JD . TP53 gene expression, correlated with 17p13 deletion, is a significant and independent adverse prognostic factor in multiple myeloma treated with high-dose therapy and auto-transplants. ASH Annu Meeting Abstr 2006; 108: 3394.

    Google Scholar 

  7. Moreau P, Attal M, Garban F, Hulin C, Facon T, Marit G et al. Heterogeneity of t(4;14) in multiple myeloma. Long-term follow-up of 100 cases treated with tandem transplantation in IFM99 trials. Leukemia 2007. Prepublished online 12 Jul 2007; doi:10.1038/sj.leu.2404832.

    Article  CAS  Google Scholar 

  8. Trudel S, Li ZH, Wei E, Wiesmann M, Chang H, Chen C et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 2005; 105: 2941–2948.

    Article  CAS  Google Scholar 

  9. Trudel S, Stewart AK, Rom E, Wei E, Li ZH, Kotzer S et al. The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells. Blood 2006; 107: 4039–4046.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology-Oncology, Comprehensive Cancer Center, Mayo Clinic, Scottsdale, AZ, USA

    W J Chng, P L Bergsagel & R Fonseca

  2. Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA

    W M Kuehl

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  1. W J Chng
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  2. W M Kuehl
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  3. P L Bergsagel
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  4. R Fonseca
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Correspondence to W J Chng.

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None is declared.

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Chng, W., Kuehl, W., Bergsagel, P. et al. Translocation t(4;14) retains prognostic significance even in the setting of high-risk molecular signature. Leukemia 22, 459–461 (2008). https://doi.org/10.1038/sj.leu.2404934

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