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Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma

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References

  1. Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Kuppers R et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001; 412: 341–346.

    Article  CAS  Google Scholar 

  2. Gu Y, Jasti AC, Jansen M, Siefring JE . RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells. Blood 2005; 105: 1467–1475.

    Article  CAS  Google Scholar 

  3. Cherry LK, Li X, Schwab P, Lim B, Klickstein LB . RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes. Nat Immunol 2004; 5: 961–967.

    Article  CAS  Google Scholar 

  4. Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B . The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol 2002; 22: 1158–1171.

    Article  CAS  Google Scholar 

  5. Liso A, Capello D, Marafioti T, Tiacci E, Cerri M, Distler V et al. Aberrant somatic hypermutation in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma. Blood 2006; 108: 1013–1020.

    Article  CAS  Google Scholar 

  6. Dijkman R, Tensen CP, Buettner M, Niedobitek G, Willemze R, Vermeer MH . Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID. Blood 2006; 107: 4926–4929.

    Article  CAS  Google Scholar 

  7. Libra M, Capello D, Gloghini A, Laura P, Berra E, Cerri M et al. Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection. J Pathol 2005; 206: 87–91.

    Article  CAS  Google Scholar 

  8. Kiyoi H, Yamaji S, Kojima S, Naoe T . JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Leukemia 2007; 21: 574–576.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by Grants-in-Aid from the Sankyo Foundation of Life Science, National Institute of Biomedical Innovation and the Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology, Japan. We thank Ms Satomi Yamaji and Chika Wakamatsu for their excellent technical help.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

    J Hiraga, A Katsumi, T Iwasaki, A Abe, T Matsushita, T Kinoshita & T Naoe

  2. Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

    H Kiyoi

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  1. J Hiraga
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  2. A Katsumi
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  3. T Iwasaki
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  4. A Abe
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  5. H Kiyoi
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  6. T Matsushita
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  7. T Kinoshita
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  8. T Naoe
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Correspondence to A Katsumi.

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Hiraga, J., Katsumi, A., Iwasaki, T. et al. Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. Leukemia 21, 1846–1847 (2007). https://doi.org/10.1038/sj.leu.2404717

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