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Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells

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References

  1. Sirohi B, Powles R . Multiple myeloma. Lancet 2004; 363: 875–887.

    Article  Google Scholar 

  2. Zipori D, Duksin D, Tamir M, Argaman A, Toledo J, Malik Z . Cultured mouse marrow stromal cell lines. II. Distinct subtypes differing in morphology, collagen types, myelopoietic factors, and leukemic cell growth modulating activities. J Cell Physiol 1985; 122: 81–90.

    Article  CAS  Google Scholar 

  3. Belaid Z, Hubint F, Humblet C, Boniver J, Nusgens B, Defresne MP . Differential expression of vascular endothelial growth factor and its receptors in hematopoietic and fatty bone marrow: evidence that neuropilin-1 is produced by fat cells. Haematologica 2005; 90: 400–401.

    CAS  PubMed  Google Scholar 

  4. Vanderkerken K, Asosingh K, Willems A, De Raeve H, Couck P, Gorus F et al. The 5T2MM murine model of multiple myeloma: maintenance and analysis. Methods Mol Med 2005; 113: 191–205.

    PubMed  Google Scholar 

  5. Kumar S, Greipp PR, Haug J, Kline M, Chng WJ, Blood E et al. Gene expression profiling of myeloma cells at diagnosis can predict response to therapy with thalidomide and dexamethasone combination. ASH Annual Meeting Abstracts 2005; 106: 508.

    Google Scholar 

  6. Vanderkerken K, De Greef C, Asosingh K, Arteta B, De Veerman M, Vande Broek I et al. Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse. Br J Cancer 2000; 82: 953–959.

    Article  CAS  Google Scholar 

  7. Alexandrakis MG, Passam FH, Sfiridaki A, Pappa CA, Moschandrea JA, Kandidakis E et al. Serum levels of leptin in multiple myeloma patients and its relation to angiogenic and inflammatory cytokines. Int J Biol Markers 2004; 19: 52–57.

    Article  CAS  Google Scholar 

  8. Gimble JM, Robinson CE, Wu X, Kelly KA . The function of adipocytes in the bone marrow stroma: an update. Bone 1996; 19: 421–428.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was financially supported by the Onderzoeksraad-VUB, the Fund for Scientific Research-Vlaanderen (FWO-Vlaanderen), the Belgian Federation against Cancer, the Association for International Cancer Research and Willy Gepts Foundation(AZ-VUB). K Vanderkerken is a post-doctoral fellow of FWO-Vlaanderen. We also thank Angelo Willems and Carine Seynaeve for excellent technical assistance.

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Authors and Affiliations

  1. Laboratory of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium

    J Caers, S Deleu, E Van Valckenborgh, E De Bruyne, I Van Riet, B Van Camp & K Vanderkerken

  2. Laboratory of Histology and Cytology, Université de Liege, Liege, Belgium

    Z Belaid & M-P DeFresne

  3. Department of Pathology, Antwerp University, Antwerp, Belgium

    H De Raeve

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  1. J Caers
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  2. S Deleu
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  3. Z Belaid
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  4. H De Raeve
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  5. E Van Valckenborgh
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  6. E De Bruyne
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  7. M-P DeFresne
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  8. I Van Riet
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  9. B Van Camp
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  10. K Vanderkerken
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Correspondence to K Vanderkerken.

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Caers, J., Deleu, S., Belaid, Z. et al. Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells. Leukemia 21, 1580–1584 (2007). https://doi.org/10.1038/sj.leu.2404658

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