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t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene

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References

  1. James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005; 434: 1144–1148.

    Article  CAS  Google Scholar 

  2. Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005; 352: 1779–1790.

    Article  CAS  Google Scholar 

  3. Storlazzi CT, Anelli L, Albano F, Zagaria A, Ventura M, Rocchi M et al. A novel chromosomal translocation t(3;7)(q26;q21) in myeloid leukemia resulting in overexpression of EVI1. Ann Hematol 2004; 83: 78–83.

    Article  CAS  Google Scholar 

  4. Borrmann L, Wilkening S, Bullerdiek J . The expression of HMGA genes is regulated by their 3'UTR. Oncogene 2001; 20: 4537–4541.

    Article  CAS  Google Scholar 

  5. Stenman G . Fusion oncogenes and tumor type specificity – insights from salivary gland tumors. Semin Cancer Biol 2005; 15: 224–235.

    Article  CAS  Google Scholar 

  6. Andrieux J, Demory JL, Dupriez B, Quief S, Plantier I, Roumier C et al. Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia. Genes Chromosomes Cancer 2004; 39: 82–87.

    Article  CAS  Google Scholar 

  7. Odero MD, Grand FH, Iqbal S, Ross F, Roman JP, Vizmanos JL et al. Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies. Leukemia 2005; 19: 245–252.

    Article  CAS  Google Scholar 

  8. Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y . TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. J Biol Chem 1999; 274: 30729–30737.

    Article  CAS  Google Scholar 

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Acknowledgements

This work has been supported by AIRC (Associazione Italiana per la Ricerca sul Cancro), MIUR (Ministero dell’Istruzione, dell’Università e della Ricerca). We thank Dr P Iuzzolino and Dr G Piccolini for their contribution to the study, and Ms MVC Pragnell, BA, for language revision of this paper.

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Authors and Affiliations

  1. Department of Genetics and Microbiology, University of Bari, Bari, Italy

    C T Storlazzi, A Lonoce, M C Guastadisegni, L Impera, P D'Addabbo & M Rocchi

  2. Hematology, University of Bari, Bari, Italy

    F Albano & G Specchia

  3. Servizio di Anatomia Patologica, Ospedale S Martino, Belluno, Italy

    C Locunsolo & S Funes

  4. Reparto di Medicina, Ospedale S. Martino, Belluno, Italy

    L Cimarosto

  5. Department of Clinical Genetics, University Hospital, Lund, Sweden

    I Panagopoulos

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  1. C T Storlazzi
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  2. F Albano
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  3. C Locunsolo
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  4. A Lonoce
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  5. S Funes
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  6. M C Guastadisegni
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  7. L Cimarosto
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  8. L Impera
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  9. P D'Addabbo
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  10. I Panagopoulos
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  11. G Specchia
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  12. M Rocchi
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Storlazzi, C., Albano, F., Locunsolo, C. et al. t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene. Leukemia 20, 2190–2192 (2006). https://doi.org/10.1038/sj.leu.2404418

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