Skip to main content
SpringerLink
Log in

Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34+ selected allogeneic hematopoietic cell transplantation

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

References

  1. Goldman JM, Melo JV . Chronic myeloid leukemia – advances in biology and new approaches to treatment. N Engl J Med 2003; 349: 1451–1464.

    Article  CAS  Google Scholar 

  2. Marmont AM, Horowitz MM, Gale RP, Sobocinski K, Ash RC, van Bekkum DW et al. T-cell depletion of HLA-identical transplants in leukemia. Blood 1991; 78: 2120–2130.

    CAS  Google Scholar 

  3. Luznik L, Fuchs EJ . Donor lymphocyte infusions to treat hematologic malignancies in relapse after allogeneic blood or marrow transplantation. Cancer Control 2002; 9: 123–137.

    Article  Google Scholar 

  4. Molldrem JJ, Lee PP, Wang C, Felio K, Kantarjian HM, Champlin RE et al. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med 2000; 6: 1018–1023.

    Article  CAS  Google Scholar 

  5. Yotnda P, Firat H, Garcia-Pons F, Garcia Z, Gourru G, Vernant JP et al. Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia. J Clin Invest 1998; 101: 2290–2296.

    Article  CAS  Google Scholar 

  6. Norbury LC, Clark RE, Christmas SE . b3a2 BCR-ABL fusion peptides as targets for cytotoxic T cells in chronic myeloid leukaemia. Br J Haematol 2000; 109: 616–621.

    Article  CAS  Google Scholar 

  7. Butt NM, Rojas JM, Wang L, Christmas SE, Abu-Eisha HM, Clark RE . Circulating bcr-abl-specific CD8+ T cells in chronic myeloid leukemia patients and healthy subjects. Haematologica 2005; 90: 1315–1323.

    CAS  PubMed  Google Scholar 

  8. Babatz J, Rollig C, Lobel B, Folbrecht G, Haack M, Gunther H et al. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. Cancer Immunol Immun 2006; 55: 268–276.

    Article  CAS  Google Scholar 

  9. Kiessling A, Schmitz M, Stevanovic S, Weigle B, Holig K, Fussel M et al. Prostate stem cell antigen: identification of immunogenic peptides and assessment of reactive CD8+ T cells in prostate cancer patients. Int J Cancer 2002; 102: 390–397.

    Article  CAS  Google Scholar 

  10. Falkenburg JH, Wafelman AR, Joosten P, Smit WM, van Bergen CA, Bongaerts R et al. Complete remission of accelerated phase chronic myeloid leukemia by treatment with leukemia-reactive cytotoxic T lymphocytes. Blood 1999; 94: 1201–1208.

    CAS  Google Scholar 

  11. Elmaagacli AH, Peceny R, Steckel N, Trenschel R, Ottinger H, Grosse-Wilde H et al. Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic phase chronic myeloid leukemia. Blood 2003; 101: 446–453.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to thank Bärbel Löbel, Diana Döhler, Verona Schwarze, Anja Maiwald and Anja Zenkel for the excellent technical assistance as well as Michelle Meredyth-Stewart for proof-reading of the manuscript. This work was supported in part by the Deutsche Krebshilfe Grant 70-2755 (MB and CT) and 70-2980 (MB and MS).

Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany

    M Bornhauser, C Thiede, J Babatz, J Schetelig, T Illmer, A Kiani, U Platzbecker & G Ehninger

  2. Medizinische Klinik und Poliklinik III, University Hospital, Mainz, Germany

    W Herr

  3. Institute for Immunology, University Hospital, Dresden, Germany

    E-P Rieber & M Schmitz

Authors
  1. M Bornhauser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C Thiede
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J Babatz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Schetelig
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T Illmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A Kiani
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. U Platzbecker
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. W Herr
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. E-P Rieber
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. G Ehninger
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. M Schmitz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bornhauser, M., Thiede, C., Babatz, J. et al. Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34+ selected allogeneic hematopoietic cell transplantation. Leukemia 20, 2055–2057 (2006). https://doi.org/10.1038/sj.leu.2404383

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404383

  • Springer Nature Limited

This article is cited by

Search

Navigation