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Screening of JAK2 V617F mutation in multiple myeloma

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References

  1. Baxter EJ, Scott LM, Campbell PJ, East C, Fourclas N, Swanton S, et al., Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005; 365: 1054–1061.

    Article  CAS  PubMed  Google Scholar 

  2. Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E et al. The JAK2 activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukaemia, but not in acute lymphoblastic leukaemia or chronic lymphocytic leukaemia. Blood 2005; 106: 3377–3379.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sulong S, Case M, Minto L, Wilkins B, Hall A, Irving J . The V617F mutation in JAK2 is not found in childhood acute lymphoblastic leukemia. BrJ Haematol 2005; 130: 964–972.

    Article  Google Scholar 

  4. Melzner I, Weniger MA, Menz CK, Moller P . Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma. Leukemia 2006; 20: 157–158.

    Article  CAS  PubMed  Google Scholar 

  5. Scott LM, Campbell PJ, Baxter EJ, Todd T, Stephens P, Edkins S et al. The V617F JAK2 mutation is uncommon in cancers and myeloid malignancies other than the classic myeloproliferative disorders. Blood 2005; 106: 2920–2921.

    Article  CAS  PubMed  Google Scholar 

  6. De Vos J, Jourdan M, Tarte K, Jasmin C, Klein B . JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br J Haematol 2000; 109: 823–828.

    Article  CAS  PubMed  Google Scholar 

  7. Abroun S, Ishikawa H, Tsuyama N, Liu S, Otsuyama KM, Zheng X et al. Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-1 in myeloma cells that highly express IL-6 receptor alpha. Blood 2004; 103: 2291–2298.

    Article  CAS  PubMed  Google Scholar 

  8. Bergsagel PL, Masellis S, Szczepek A, Mant MJ, Belch AR, Pilarski LM . In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56 and monotypic immunoglobulin light chain. Blood 1995; 85: 436–447.

    CAS  PubMed  Google Scholar 

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Fiorini, A., Farina, G., Reddiconto, G. et al. Screening of JAK2 V617F mutation in multiple myeloma. Leukemia 20, 1912–1913 (2006). https://doi.org/10.1038/sj.leu.2404332

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