Skip to main content

Advertisement

Log in

Loss of Zap-70 and low molecular weight phosphotyrosine phosphatase occurs after therapy in a patient with B-chronic lymphocytic leukemia

  • Correspondence
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1

References

  1. Chen L, Widhopf G, Huynh L, Rassenti L, Rai KR, Weiss A et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002; 100: 4609–4614.

    Article  CAS  Google Scholar 

  2. Watts JD, Affolter M, Krebs DL, Wange RL, Samelson LE, Aebersold R . Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J Biol Chem 1994; 269: 29520–29529.

    CAS  PubMed  Google Scholar 

  3. Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT et al. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem 2002; 277: 24220–24224.

    Article  CAS  Google Scholar 

  4. Chiarugi P, Taddei ML, Schiavone N, Papucci L, Giannoni E, Fiaschi T et al. LMW-PTP is a positive regulator of tumor onset and growth. Oncogene 2004; 23: 3905–3914.

    Article  CAS  Google Scholar 

  5. Miller DT, Read R, Rusconi J, Cagan RL . The Drosophila primo locus encodes two low-molecular-weight tyrosine phosphatases. Gene 2000; 243: 1–9.

    Article  CAS  Google Scholar 

  6. Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE et al. M. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome and distinct gene expression profile. Blood 2003; 101: 4944–4951.

    Article  CAS  Google Scholar 

  7. Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.

    Article  CAS  Google Scholar 

  8. Rassenti LZ, Huynh L, Toy TL, Chen L, Keating MJ, Gribben JG et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004; 351: 893–901.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Dr Z Chen has been supported in part by the Chinese National Key Program for Basic Research (973, 001CB510103) and a grant from the Chinese National Science Fund for Distinguished Young Scholars (30225038). Dr M Yu has been supported by the American Society of Clinical Oncology Clinical Research Career Development Award and the Huntsman Cancer Institute Translational Research Program.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M K Yu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, Z., Aston, E. & Yu, M. Loss of Zap-70 and low molecular weight phosphotyrosine phosphatase occurs after therapy in a patient with B-chronic lymphocytic leukemia. Leukemia 19, 1503–1505 (2005). https://doi.org/10.1038/sj.leu.2403793

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403793

  • Springer Nature Limited

This article is cited by

Navigation