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e8a2 BCR–ABL: more frequent than other atypical BCR–ABL variants?

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References

  1. Melo JV . The diversity of BCR–ABL fusion proteins and their relationship to leukemia phenotype. Blood 1996; 88: 2375–2384.

    CAS  Google Scholar 

  2. Martinelli G, Amabile M, Giannini B, Terragna C, Ottaviani E, Soverini S et al. Novel types of bcr–abl transcript with breakpoints in BCR exon 8 found in Philadelphia positive patients with typical chronic myeloid leukemia retain the sequence encoding for the DBL- and CDC24 homology domains but not the pleckstrin homology one. Haematologica 2002; 87: 688–694.

    CAS  PubMed  Google Scholar 

  3. Schultheis B, Wang L, Clark RE, Melo JV . BCR–ABL with an e6a2 fusion in a CML patient diagnosed in blast crisis. Leukemia 2003; 17: 2054–2055.

    Article  CAS  Google Scholar 

  4. Lemmon MA, Ferguson KM . Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J 2000; 350 (Part 1): 1–18.

    Article  CAS  Google Scholar 

  5. Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD et al. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 1998; 279: 558–560.

    Article  CAS  Google Scholar 

  6. Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, Bokoch GM . Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci USA 1995; 92: 10282–10286.

    Article  CAS  Google Scholar 

  7. Lugo TG, Pendergast AM, Muller AJ, Witte ON . Tyrosine kinase activity and transformation potency of bcr–abl oncogene products. Science 1990; 247: 1079–1082.

    Article  CAS  Google Scholar 

  8. Kin Y, Li G, Shibuya M, Maru Y . The Dbl homology domain of BCR is not a simple spacer in P210 BCR–ABL of the Philadelphia chromosome. J Biol Chem 2001; 276: 39462–39468.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Oregon Health & Science University Cancer Institute, Portland, OR, USA

    S Demehri, B J Druker & M W N Deininger

  2. III. Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany

    P Paschka, B Schultheis & A Hochhaus

  3. Department of Hematology, University of Leipzig, Germany

    T Lange

  4. Clinical Research Division, Hyogo Medical Center for Adults, Akashi, Japan

    T Koizumi & T Sugimoto

  5. Institute of Medical and Veterinary Science, South Australia

    S Branford

  6. Department of Hematology, Singapore General Hospital, Singapore

    L-C Lim

  7. Department of Hematology/Oncology, University of Halle-Wittenberg, Germany

    T Kegel

  8. Institute of Hematology and Medical Oncology Seragnoli, University of Bologna, Italy

    G Martinelli

  9. Howard Hughes Medical Institute, Portland, OR, USA

    B J Druker

Authors
  1. S Demehri
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  2. P Paschka
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  3. B Schultheis
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  4. T Lange
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  5. T Koizumi
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  6. T Sugimoto
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  7. S Branford
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  8. L-C Lim
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  9. T Kegel
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  10. G Martinelli
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  11. A Hochhaus
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  12. B J Druker
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  13. M W N Deininger
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Corresponding author

Correspondence to M W N Deininger.

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Demehri, S., Paschka, P., Schultheis, B. et al. e8a2 BCR–ABL: more frequent than other atypical BCR–ABL variants?. Leukemia 19, 681–684 (2005). https://doi.org/10.1038/sj.leu.2403604

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  • DOI: https://doi.org/10.1038/sj.leu.2403604

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