Skip to main content

Advertisement

SpringerLink
Log in

Altered splicing in hematological malignancies reveals a tissue-specific translational block of the Src-family tyrosine kinase fyn brain isoform expression

  • Correspondence
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3

References

  1. Yeatman TJ . A renaissance for Src. Nat Rev Cancer 2004; 4: 470–480.

    Article  CAS  PubMed  Google Scholar 

  2. Cooke MP, Perlmutter RM . Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. New Biol 1989; 1: 66–74.

    CAS  PubMed  Google Scholar 

  3. Picard C, Gilles A, Pontarotti P, Olive D, Collette Y . Cutting edge: recruitment of the ancestral fyn gene during emergence of the adaptive immune system. J Immunol 2002; 168: 2595–2598.

    Article  CAS  PubMed  Google Scholar 

  4. Davidson D, Chow LM, Fournel M, Veillette A . Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn. J Exp Med 1992; 175: 1483–1492.

    Article  CAS  PubMed  Google Scholar 

  5. Davidson D, Fournel M, Veillette A . Oncogenic activation of p59fyn tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528. J Biol Chem 1994; 269: 10956–10963.

    CAS  PubMed  Google Scholar 

  6. Weil R, Levraud JP, Dodon MD, Bessia C, Hazan U, Kourilsky P et al. Altered expression of tyrosine kinases of the Src, Syk families in human T-cell leukemia virus type 1-infected T-cell lines. J Virol 1999; 73: 3709–3717.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Moderek B, Lee C . A genomic view of alternative splicing. Nat Genet 2002; 30: 13–19.

    Article  Google Scholar 

  8. Lee C, Kim MG, Jeon SH, Park SD, Seong RH . Two species of mRNA for the fyn proto-oncogene are produced by an alternative polyadenylation. Mol Cells 1998; 8: 746–749.

    CAS  PubMed  Google Scholar 

  9. Berwanger B, Hartmann O, Bergmann E, Bernard S, Nielsen D, Krause M et al. Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma. Cancer Cell 2002; 2: 377–386.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Département de Biochimie et de Biologie Moléculaire, Hôpital Universitaire Nord, IFR Jean Roche, Université de la Méditerranée, Marseilles cedex, France

    C Picard & J Gabert

  2. Institut de Recherches sur le Cancer de Marseille, Université de la Méditerranée, Marseilles, France

    C Picard, D Olive & Y Collette

Authors
  1. C Picard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Gabert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D Olive
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y Collette
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y Collette.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Picard, C., Gabert, J., Olive, D. et al. Altered splicing in hematological malignancies reveals a tissue-specific translational block of the Src-family tyrosine kinase fyn brain isoform expression. Leukemia 18, 1737–1739 (2004). https://doi.org/10.1038/sj.leu.2403499

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403499

  • Springer Nature Limited

Search

Navigation