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Fusion of AML1/Runx1 to Copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation

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References

  1. Lutterbach B, Hiebert SW . Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 2000; 245: 223–235.

    Article  CAS  Google Scholar 

  2. Speck NA, Gilliland DG . Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2002; 2: 502–513.

    Article  CAS  Google Scholar 

  3. Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y et al. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Blood 1998; 91: 4028–4037.

    CAS  Google Scholar 

  4. Zent CS, Mathieu C, Claxton DF, Zhang DE, Tenen DG, Rowley JD et al. The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties. Proc Natl Acad Sci USA. 1996; 93: 1044–1048.

    Article  CAS  Google Scholar 

  5. Hromas R, Shopnick R, Jumean HG, Bowers C, Varella-Garcia M, Richkind K . A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. Blood 2000; 95: 4011–4013.

    CAS  PubMed  Google Scholar 

  6. Hromas R, Busse T, Carroll A, Mack D, Shopnick R, Zhang D-E et al. Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein. Blood 2001; 97: 2168–2170.

    Article  CAS  Google Scholar 

  7. Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J et al. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. J Biol Chem 1998; 273: 1393–1402.

    Article  CAS  Google Scholar 

  8. Hua J, Grisafi P, Cheng SH, Fink GR . Plant growth homeostasis is controlled by the Arabidopsis BON1 and BAP1 genes. Genes Dev 2001; 15: 2263–2272.

    Article  CAS  Google Scholar 

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Ramsey, H., Zhang, DE., Richkind, K. et al. Fusion of AML1/Runx1 to Copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation. Leukemia 17, 1665–1666 (2003). https://doi.org/10.1038/sj.leu.2403048

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