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Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

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References

  1. Jordan CT . Unique molecular and cellular features of acute myelogenous leukemia stem cells. Leukemia 2002; 16: 559–562.

    Article  CAS  Google Scholar 

  2. Tse KF, Mukherjee G, Small D . Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia 2000; 14: 1766–1776.

    Article  CAS  Google Scholar 

  3. Lee JT Jr, McCubrey JA . The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 2002; 16: 486–507.

    Article  CAS  Google Scholar 

  4. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 1997; 7: 261–269.

    Article  CAS  Google Scholar 

  5. Hsu J, Shi Y, Krajewski S, Renner S, Fisher M, Reed JC et al. The Akt kinase is activated in multiple myeloma tumor cells. Blood 2001; 98: 2853–2855.

    Article  CAS  Google Scholar 

  6. Nicholson KM, Anderson NG . The protein kinase B/Akt signall-ing pathway in human malignancy. Cell Signal 2002; 14: 381–395.

    Article  CAS  Google Scholar 

  7. Brognard J, Clark AS, Ni Y, Dennis PA . Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 2001; 61: 3986–3997.

    CAS  PubMed  Google Scholar 

  8. Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ et al. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999; 274: 21528–21532.

    Article  CAS  Google Scholar 

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Acknowledgements

This study was supported by a grant of the Korea Health Ministry of Health & Welfare, Republic of Korea (02-PJ1-PG3-20802-0005).

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Authors and Affiliations

  1. Department of Internal Medicine, Seoul, Korea

    Y H Min, J W Cheong, H O Maeng, S T Lee, J S Hahn & Y W Ko

  2. Clinical Research Center, Seoul, Korea

    J I Eom, J Y Kim & H K Jeung

  3. BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

    Y H Min

  4. Department of Internal Medicine, Sunggeuankwan University, School of Medicine, Samsung Medical Center, Seoul, Korea

    M H Lee

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  1. Y H Min
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  2. J I Eom
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Min, Y., Eom, J., Cheong, J. et al. Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 17, 995–997 (2003). https://doi.org/10.1038/sj.leu.2402874

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  • DOI: https://doi.org/10.1038/sj.leu.2402874

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