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References
Cavé H, van der Werff ten Bosch J, Suciu S, Guidal C, Waterkeyn C, Otten J, Bakkus M, Thielemans K, Grandchamp B, Vilmer E . Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer-Childhood Leukemia Cooperative Group N Engl J Med 1998 339: 591–598
van Dongen JJ, Seriu T, Panzer-Grumayer ER, Biondi A, Pongers-Willemse MJ, Corral L, Stolz F, Schrappe M, Masera G, Kamps WA, Gadner H, van Wering ER, Ludwig WD, Basso G, de Bruijn MA, Cazzaniga G, Hettinger K, van der Does-van den Berg A, Hop WC, Riehm H, Bartram CR . Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood Lancet 1998 28: 1731–1738
Elsworth AM, Evans PAS, Morgan GJ, Kinsey SE, Shiach CR . Quantitative PCR of the immunoglobulin heavy chain gene using genomic DNA Br J Haematol 1996 95: 700–703
Owen RG, Goulden NJ, Oackhill A, Shiach C, Evans PA, Potter MN . Comparison of fluorescent consensus IgH PCR and allele-specific oligonucleotide probing in the detection of minimal residual disease in childhood ALL Br J Haematol 1997 97: 457–459
Cavé H, Guidal C, Rohrlich P, Delfau MH, Broyard A, Lescoeur B, Rahimy C, Fenneteau O, Monplaisir N, d'Auriol L, Vilmer E, Grandchamp B . Prospective monitoring and quantitation of residual blasts in childhood acute lymphoblastic leukemia by polymerase chain reaction study of δ and γ T-cell receptor genes Blood 1994 83: 1892–1902
Trainor KJ, Brisco MJ, Wan JH, Neoh S, Grist S, Morley AA . Gene rearrangement in B- and T- lymphoproliferative disease detected by the polymerase chain reaction Blood 1991 78: 192–196
Szczepanski T, Langerak AW, Wolvers-Tettero IL, Ossenkoppele GJ, Verhoef G, Stul M, Petersen EJ, de Bruijn MA, van't Veer MB, van Dongen JJ . Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease Leukemia 1998 12: 1081–1088
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Guidal, C., Vilmer, E., Grandchamp, B. et al. A competitive PCR-based method using TCRD, TCRG and IGH rearrangements for rapid detection of patients with high levels of minimal residual disease in acute lymphoblastic leukemia. Leukemia 16, 762–764 (2002). https://doi.org/10.1038/sj.leu.2402396
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DOI: https://doi.org/10.1038/sj.leu.2402396
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