Abstract
The development of therapy-related acute myeloid leukemia (t-AML) has become a growing concern over the past decade, because of the increase in the percentage of long-term survivors of primary malignancy. We reviewed 17 cases with etoposide-related acute promyelocytic leukemia (APL) reported in the literature. The close association between treatment with etoposide for Langerhans cell histiocytosis (LCH) and the development of etoposide-related APL was demonstrated among Japanese and Italians. Our data on the breakpoints (b/ps) of the PML and RARα genes are presented. It is suggested that chromatin structure might be more important than specific consensus sequence in the distribution of b/ps in etoposide-related APL.
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Kudo, K., Yoshida, H., Kiyoi, H. et al. Etoposide-related acute promyelocytic leukemia. Leukemia 12, 1171–1175 (1998). https://doi.org/10.1038/sj.leu.2401089
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DOI: https://doi.org/10.1038/sj.leu.2401089
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