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The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients

  • European Union Concerted Action Workshop on 11q23
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Abstract

The clinical, haematological and cytogenetic data for 20 patients with an acquired abnormality of 11q23 and 10p have been reviewed at this workshop. Patients predominantly presented with de novo AML M5a and the most common cytogenetic finding was an inversion of part of the long arm of chromosome 11 followed by a translocation between 11q and 10p. Band p12 represented the most common breakpoint on chromosome 10. The t(10;11) subgroup defined a subset of younger 11q23 patients, the majority of whom achieve a first complete remission despite the differing treatment regimens.

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Authors and Affiliations

  1. ICRF Department of Medical Oncology, St Bartholomew’s Hospital Medical College, London, UK

    DM Lillington & BD Young

  2. Institute of Genetique Moleculaire, Paris, France

    R Berger

  3. The Royal Free Hospital School of Medicine, London, UK

    M Martineau, AV Moorman & LM Secker-Walker

Authors
  1. DM Lillington
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  2. BD Young
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  3. R Berger
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  4. M Martineau
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  5. AV Moorman
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  6. LM Secker-Walker
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Lillington, D., Young, B., Berger, R. et al. The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients. Leukemia 12, 801–804 (1998). https://doi.org/10.1038/sj.leu.2401015

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  • DOI: https://doi.org/10.1038/sj.leu.2401015

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