Skip to main content
SpringerLink
Log in

Perinatal/Neonatal Case Presentation

Daptomycin use in infants: report of two cases with peak and trough drug concentrations

  • Perinatal/Neonatal Case Presentation
  • Published:
Journal of Perinatology Submit manuscript

Abstract

We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml−1, and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml−1, respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fda.gov [homepage on the Internet]. Maryland: Food and Drug Administration 2003, available from: http://www.fda.gov/.

  2. Dvorchik BH, Brazier D, DeBruin MF, Arbeit RD . Daptomycin pharmacokinetics and safety following administration of escalating doses once daily to healthy subjects. Antimicrob Agents Chemother 2003; 47 (4): 1318–1323.

    Article  CAS  Google Scholar 

  3. Kearns GL, Jacobs RF, Jafri HS, Hong EF, Benziger DP . Pharmacokinetics of daptomycin in pediatric patients. PAS 2007: Pediatric Academic Societies' Annual Meeting, Toronto; 2007 May 5–8; Toronto, Canada 2007.

Download references

Acknowledgements

This work was supported by the Pediatric Pharmacology Research Unit Network. Dr Cohen-Wolkowiez received support from the Lenox Baker fellowship and is the Lenox Baker Fellow. Dr Smith received support from T32 (HD-043728-01A2). Dr Benjamin received support from K23 (HD-044799-01) and 5U10 HD045962-03. Dr Wade received support from the Pediatric Pharmacology Research Unit (U01 HD037255-06). The assay of daptomycin concentrations was performed by Cubist Pharmaceuticals. We thank Dr Gordon Worley and the board of directors at the Lenox Baker Children's Hospital for their support during this project. There is no statistical support for this article.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Duke University, Durham, NC, USA

    M Cohen-Wolkowiez, P B Smith & D K Benjamin Jr

  2. Duke University Clinical Research Institute, Durham, NC, USA

    P B Smith & D K Benjamin Jr

  3. Department of Medicine, Duke University, Durham, NC, USA

    V G Fowler Jr

  4. Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA

    K C Wade

Authors
  1. M Cohen-Wolkowiez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P B Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D K Benjamin Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V G Fowler Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K C Wade
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D K Benjamin Jr.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cohen-Wolkowiez, M., Smith, P., Benjamin, D. et al. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol 28, 233–234 (2008). https://doi.org/10.1038/sj.jp.7211898

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7211898

  • Springer Nature America, Inc.

Keywords

This article is cited by

Search

Navigation