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Maternal Floor Infarction of the Placenta: Association With Central Nervous System Injury and Adverse Neurodevelopmental Outcome

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Abstract

OBJECTIVE: To compare cranial ultrasound studies and neurodevelopmental outcome of preterm infants affected by maternal floor infarction (MFI) of the placenta to gestational age-matched controls over an 8-year period from a single institution.

STUDY DESIGN: Retrospective case/control study.

RESULTS: Compared to gestational age-matched controls, infants born to mothers with MFI had a higher incidence of CNS injury on neonatal cranial ultrasound examinations and at follow-up were more likely to have a suspicious or abnormal neurologic examination. MFI cases had lower developmental scores in all areas tested and were more likely to have neurodevelopmental impairment.

CONCLUSION: Infants born to mothers with MFI should have serial neonatal cranial ultrasound examinations to detect CNS injury and neurodevelopmental assessment during early childhood.

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References

  1. Benirschke K, Driscoll SG . Maternal Floor Infarction. Pathology of the Human Placenta New York: Springer-Verlag; 1967 pp 328–30

  2. Andres RL, Kuyper W, Resnik R, Piacquadio KM, Benirschke K . The association of maternal floor infarction of the placenta with adverse perinatal outcome Am J Obstet Gynecol 1990 163: 935–8

    Article  CAS  Google Scholar 

  3. Mandsager NT, Bendon R, Mostello D, Rosenn B, Miodovnik M, Siddiqi TA . Maternal floor infarction of the placenta: prenatal diagnosis and clinical significance Obstet Gynecol 1994 83: 750–4

    CAS  PubMed  Google Scholar 

  4. Vernof KK, Benirschke K, Kephart GM, Wasmoen TL, Gleich GJ . Maternal floor infarction: relationship to X cells, major basic protein, and adverse perinatal outcome Am J Obstet Gynecol 1992 167: 1355–63

    Article  CAS  Google Scholar 

  5. Benirschke K, Kaufmann . Pathology of the Human Placenta 1995 pp 245–50

    Chapter  Google Scholar 

  6. Naeye RL . Maternal floor infarction Hum Pathol 1985 16: 823–8

    Article  CAS  Google Scholar 

  7. Dubowitz L . Assessment of gestational age in newborn: a practical scoring system Arch Dis Child 1969 44: 782

    Article  CAS  Google Scholar 

  8. Usher R, McLean F . Intrauterine growth of live-born Caucasian infants at sea level: standards obtained from measurement in 7 dimensions of infants between 25 and 44 weeks gestation J Pediatr 1969 74: 901–10

    Article  CAS  Google Scholar 

  9. Bejar R, Wozniak P, Allard M et al. Antenatal origin of neurologic damage in newborn infants Am J Obstet Gynecol 1988 159: 357–63

    Article  CAS  Google Scholar 

  10. Papille LA, Burstein J, Burstein R et al. Incidence and evolution of subependymal and intraventricular hemorrhage J Pediatr 1978 92: 529–34

    Article  Google Scholar 

  11. Pinto-Martin JA, Riolo S, Cnaan A, Holzman C, Susser MW, Paneth N . Cranial ultrasound prediction of disabling and nondisabling cerebral palsy at age two in a low birth weight population Pediatrics 1995 95: 249–54

    CAS  PubMed  Google Scholar 

  12. Amiel-Tison C, Grenier A . Neurologic Assessment During the First Year of Life New York: Oxford Press 1986

    Google Scholar 

  13. Knobloch H, Stevens F, Malone AF . Manual of Developmental Diagnosis 1980 p 1–286

  14. Bayley N . Bayley Scales of Infant Development New York, NY: Psychological Corporation 1969

    Google Scholar 

  15. Sparrow SS, Balla DA, Ciccheti DV . The Vineland Adaptive Behavior Scales: Survey Form Manual Circle Pines, MN: American Guidance Service 1984

    Google Scholar 

  16. Spinillo A, Capuzzo E, Stronati M, Ometto A, Orcesi S, Fazzi E . Effect of preterm premature rupture of membranes on neurodevelopmental outcome: follow-up at two years of age Br J Obstet Gynaecol 1995 102: 882–7

    Article  CAS  Google Scholar 

  17. Ballard RA, Ballard PL, Cnaan A et al. Antenatal thyrotropin-releasing hormone to prevent lung disease in preterm infants N Engl J Med 1998 338: 493–8

    Article  CAS  Google Scholar 

  18. Volpe JJ . Neurology of the Newborn 4th ed 2001 pp 307–15 and 340–6

  19. Graham M, Levene M, Trounce JQ, Rutter N . Prediction of cerebral palsy in very low birthweight infants: prospective ultrasound study Lancet 1987 593–6

  20. Murphy DJ, Hope PL, Johnson A . Ultrasound findings and clinical antecedents of cerebral palsy in very preterm infants Arch Dis Child 1996 74: F105–9

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Pediatrics/Division of Neonatology, Pathology and Reproductive Medicine, University of California at San Diego, San Diego, CA, USA

    Ira Adams-Chapman MD, Yvonne E Vaucher MPH, MD, Raul F Bejar MD, Kurt Benirschke MD, Rebecca N Baergen MD & Thomas R Moore MD

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  1. Ira Adams-Chapman MD
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  2. Yvonne E Vaucher MPH, MD
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  3. Raul F Bejar MD
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  4. Kurt Benirschke MD
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  5. Rebecca N Baergen MD
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  6. Thomas R Moore MD
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Adams-Chapman, I., Vaucher, Y., Bejar, R. et al. Maternal Floor Infarction of the Placenta: Association With Central Nervous System Injury and Adverse Neurodevelopmental Outcome. J Perinatol 22, 236–241 (2002). https://doi.org/10.1038/sj.jp.7210685

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