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Nitroglycerin for Rapid Tocolysis: Development of a Protocol and a Literature Review

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Abstract

OBJECTIVE:

A protocol for nitroglycerin (NTG) use based on experiences with regard to new and previously described obstetric cases is presented. The efficacy of NTG tocolysis for obstetric emergencies is clinically evaluated.

STUDY DESIGN:

Hemodynamically stable parturients requiring acute tocolysis were treated with intravenous NTG and closely monitored. Clinical information was subsequently abstracted from medical records and compared with data from previous reviews.

RESULTS:

Tocolytic treatment was successful in all cases (22 of 22, 100%). Complications were clinically insignificant. The most common problem was transient hypotension, which occurred in 9 of 22 (41%) cases.

CONCLUSION: NTG is an effective tocolytic with minimal complications, rapid onset, and a brief half-life. These characteristics favor its use during select obstetric procedures. However, strict adherence to protocols for administration is advised.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tufts University School of Medicine, Baystate Medical Center, Springfield, MA

    John Patrick O’Grady MD & Sejal S Patel BA

  2. Department of Anesthesiology, Tufts University School of Medicine, Baystate Medical Center, Springfield, MA

    Robert K Parker DO

Authors
  1. John Patrick O’Grady MD
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  2. Robert K Parker DO
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  3. Sejal S Patel BA
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Corresponding author

Correspondence to John Patrick O’Grady MD.

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O’Grady, J., Parker, R. & Patel, S. Nitroglycerin for Rapid Tocolysis: Development of a Protocol and a Literature Review. J Perinatol 20, 27–33 (2000). https://doi.org/10.1038/sj.jp.7200303

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  • DOI: https://doi.org/10.1038/sj.jp.7200303

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