The production of EDDS (ethylene-diamine-disuccinic acid), a potential substitute for EDTA, has been optimized up to a product concentration of 20 grams per litre in fermentations of Amycolatopsis orientalis. Decisive steps for the increase in productivity were variation of the synthetic medium composition, investigation of the influence of metal ions on product formation, controlled feeding of carbon and nitrogen sources in fed-batch fermentations and improvement of the downstream processing steps.
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Received 05 May 1997/ Accepted in revised form 13 August 1997
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Zwicker, N., Theobald, U., Zähner, H. et al. Optimization of fermentation conditions for the production of ethylene-diamine-disuccinic acid by Amycolatopsis orientalis . J Ind Microbiol Biotech 19, 280–285 (1997). https://doi.org/10.1038/sj.jim.2900458
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DOI: https://doi.org/10.1038/sj.jim.2900458