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Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension

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Abstract

Arterial stiffness is an independent predictor of cardiovascular events in a hypertensive population. Serum levels of matrix metalloproteinase (MMP)-9 are associated with arterial stiffness and predict cardiovascular risk. We investigated the role of MMP-9 polymorphism −1562C>T on blood pressure (BP) and arterial stiffness in a newly diagnosed hypertensive population. Untreated hypertensive patients (n=215, mean age 46±13 years) were studied. Supine BP, carotid-femoral pulse wave velocity (PWV) and augmentation index were assessed. Serum biochemistry and plasma MMP-9 concentrations were measured and genotyping performed following extraction of genomic DNA. BP, aortic PWV and serum MMP-9 levels were significantly higher in T-allele carriers of the −1562C>T polymorphism with a significant gene–dose effect (P<0.0001). In a stepwise regression model adjusting for known or likely determinants, the 1562C>T polymorphism emerged as an independent predictor of systolic BP (R2=0.25, P<0.0001), diastolic BP (R2=0.16, P<0.0001) and PWV (R2=0.47,P<0.0001). This is the first study to show the effect of MMP-9 polymorphism on BP and aortic stiffness in a hypertensive population. These results suggest that hypertensive patients carrying the T allele may be at increased risk of cardiovascular events.

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin, Ireland

    S Zhou, J Feely, J P Spiers & A Mahmud

  2. Hypertension Clinic, St James's Hospital, Dublin, Ireland

    J Feely & A Mahmud

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  1. S Zhou
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  2. J Feely
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  3. J P Spiers
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  4. A Mahmud
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Correspondence to A Mahmud.

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Zhou, S., Feely, J., Spiers, J. et al. Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension. J Hum Hypertens 21, 861–867 (2007). https://doi.org/10.1038/sj.jhh.1002244

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  • DOI: https://doi.org/10.1038/sj.jhh.1002244

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