Abstract
OBJECTIVE: To evaluate the association between standard and computed tomography (CT)-based measures of obesity and subclinical atherosclerosis, defined as coronary artery calcium (CAC) by Electron Beam Computed Tomography (EBCT).
DESIGN: Cross-sectional, observational study of anthropometric and CT obesity measures and presence of CAC.
SUBJECTS: Participants were 383 men and 379 women, aged 20–58 y and asymptomatic for coronary artery disease (CAD).
MEASUREMENTS: Intra-abdominal fat (IAF) and subcutaneous fat (SQF) were measured at the level of lumbar 2–3 and 4–5 spaces, using EBCT. Body mass index (BMI) was calculated from height and weight, and minimum waist circumference and maximum hip circumference were measured. CAC was measured by EBCT.
RESULTS: In both men and women, BMI, waist circumference, IAF, and SQF were significantly related to CAC. However, BMI or waist circumference explained variation in the presence of CAC as well as IAF or SQF, univariately and after adjustment for additional cardiovascular risk factors.
CONCLUSION: CT-based obesity exposure measures are not superior to BMI or waist circumference in association studies of subclinical CAD.
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Acknowledgements
Support for this study was provided by the NIH National Heart, Lung and Blood Institute Grant R01 HL61753 and DERC Clinical Investigation Core P30 DK57516. The study was performed at the Adult General Clinical Research Center at the University of Colorado Health Sciences Center supported by the NIH M01 RR00051, at the Barbara Davis Center for Childhood Diabetes in Denver, CO, and at Colorado Heart Imaging Center in Denver, CO. We thank the GCRC nursing staff and Core Laboratory, and the staff at Colorado Heart Imaging Center, for their assistance.
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Snell-Bergeon, J., Hokanson, J., Kinney, G. et al. Measurement of abdominal fat by CT compared to waist circumference and BMI in explaining the presence of coronary calcium. Int J Obes 28, 1594–1599 (2004). https://doi.org/10.1038/sj.ijo.0802796
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DOI: https://doi.org/10.1038/sj.ijo.0802796
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