Abstract
BACKGROUND: Studies examining the foetal origins hypothesis suggest that small birth size may be a marker of foetal adaptations that programme future propensity to adult disease. We explore the hypothesis that birth size may relate to fat distribution in childhood and that fat distribution may be a link between birth size and adult disease.
OBJECTIVE: To investigate the relationship between birth size and abdominal fat, blood pressure, lipids, insulin and insulin:glucose ratio in prepubertal children.
DESIGN: Cross-sectional study, based on a birth cohort of consecutive full-term births.
SUBJECTS: Two hundred and fifty-five (137 females) healthy, 7- and 8-y-old children.
MEASUREMENTS: Body composition and abdominal fat was measured by dual energy X-ray absorptiometry. Lipid, glucose and insulin profiles were measured after an overnight fast and an automated BP monitor was used for blood pressure measurements.
RESULTS: There was a negative association between abdominal fat and birth weight s.d. score across a range of normal birth weights (β=−0.18; 95% CI=−0.31 to −0.04, P=0.009) and a positive association with weight s.d. score at 7/8 y (β=0.35; 95% CI=0.24 to 0.46, P<0.001). Children who were born with the lowest weight s.d. score and had the greatest weight s.d. score at 7/8 y had significantly more (P<0.001) abdominal fat, as a percentage of total fat (6.53±1.3%) than those who had the highest birth weight s.d. score and the lowest weight s.d. score at 7/8 y (4.14±0.5%). Similar results were seen if head circumference, but not ponderal index, was used as an indicator of birth size. Increased abdominal fat was associated with higher total cholesterol:HDL cholesterol, higher triglyceride concentration and increased diastolic blood pressure.
CONCLUSIONS: Birth weight independently predicted abdominal fat. Children with the highest amount of abdominal fat were those who tended to be born lighter and gained weight centiles. Increased abdominal fat was associated with precursor risk factors for ischaemic heart disease.
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References
Barker DJ . Early growth and cardiovascular disease Arch Dis Child 1999 80: 305–310.
Boulton TJ, Cockington RA, Hamilton-Craig I, Magarey AM, Mazumdar J . A profile of heart disease risk factors and their relation to parents' education, fathers' occupation and family history of heart disease in 843 South Australian families: the Adelaide Children's WHO Collaborative Study J Paediatr Child Health 1995 31: 200–206.
Goran MI, Gower BA . Relation between visceral fat and disease risk in children and adolescents Am J Clin Nutr 1999 70: 149S–156S.
Shear CL, Freedman DS, Burke GL, Harsha DW, Berenson GS . Body fat patterning and blood pressure in children and young adults. The Bogalusa Heart Study Hypertension 1987 9: 236–244.
Daniels SR, Morrison JA, Sprecher DL, Khoury P, Kimball TR . Association of body fat distribution and cardiovascular risk factors in children and adolescents Circulation 1999 99: 541–545.
Fall CH, Osmond C, Barker DJ, Clark PM, Hales CN, Stirling Y, Meade TW . Fetal and infant growth and cardiovascular risk factors in women Br Med J 1995 310: 428–432.
Valdez R, Athens MA, Thompson GH, Bradshaw BS, Stern MP . Birthweight and adult health outcomes in a biethnic population in the USA Diabetologia 1994 37: 624–631.
Barker M, Robinson S, Osmond C, Barker DJ . Birth weight and body fat distribution in adolescent girls Arch Dis Child 1997 77: 381–383.
Malina RM, Katzmarzyk PT, Beunen G . Birth weight and its relationship to size attained and relative fat distribution at 7 to 12 y of age Obes Res 1996 4: 385–389.
Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ . Catch-up growth in childhood and death from coronary heart disease: longitudinal study Br Med J 1999 318: 427–431.
Crowther NJ, Cameron N, Trusler J, Gray IP . Association between poor glucose tolerance and rapid post natal weight gain in seven-year-old children Diabetologia 1998 41: 1163–1167.
Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB, and the Avon Longitudinal Study of Pregnancy and Childhood Study Team . Association between postnatal catch-up growth and obesity in childhood: prospective cohort study Br Med J 2000 320: 967–971.
Ogle GD, Allen JR, Humphries IR, Lu PW, Briody JN, Morley K, Howman Giles R, Cowell CT . Body-composition assessment by dual-energy X-ray absorptiometry in subjects aged 4–26 y Am J Clin Nutr 1995 61: 746–753.
Kamel EG, McNeill G, Han TS, Smith FW, Avenell A, Davies DP, Tothill P . Measurement of abdominal fat by magnetic resonance imaging, dual-energy X-ray absorptiometry and anthropometry in non-obese men and women Int J Obes Relat Metab Disord 1999 23: 686–692.
Fay RA, Dey PL, Saadie CM, Buhl JA, Gebski VJ . Ponderal index: a better definition of the ‘at risk’ group with intrauterine growth problems than birth-weight for gestational age in term infants Aust NZ J Obset Gynaecol 1991 31: 17–19.
Roberts CL, Lancaster PA . Australian national birthweight percentiles by gestational age Med J Aust 1999 170: 114–118.
Hamill PV, Drizd TA, Johnson CL, Reed RB, Roche AF, Moore WM . Physical growth: National Center for Health Statistics percentiles Am J Clin Nutr 1979 32: 607–629.
Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ . Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM Diabetes 1996 45: 633–638.
Lucas A, Fewtrell MS, Cole TJ . Fetal origins of adult disease-the hypothesis revisited Br Med J 1999 319: 245–249.
Gluckman PD, Cutfield W, Harding JE, Milner D, Jensen E, Woodhall S, Gallaher B, Bauer M, Breier BH . Metabolic consequences of intrauterine growth retardation Acta Paediatr 1996 (Suppl 417): 3–6.
Garnett S, Cowell CT, Bradford D, Lee J, Tao C, Petrauskas V, Fay RA, Baur LA . Effect of gender, body composition and birth size on IGF-I in 7 and 8 y old children Horm Res 1999 52: 221–229.
Karlberg J, Albertsson Wikland K . Growth in full-term small-for-gestational-age infants: from birth to final height Pediatr Res 1995 38: 733–739.
Moore VM, Miller AG, Boulton TJ, Cockington RA, Craig IH, Magarey AM, Robinson JS . Placental weight, birth measurements, and blood pressure at age 8 y Arch Dis Child 1996 74: 538–541.
Dwyer T, Blizzard L, Morley R, Ponsonby A . Within pair association between birth weight and blood pressure at age 8 in twins from cohort study Br Med J 1999 319: 1325–1329.
Gower BA, Nagy TR, Goran MI . Visceral fat, insulin sensitivity, and lipids in prepubertal children Diabetes 1999 48: 1515–1521.
Acknowledgements
We would like to thank all the families that generously donated their time to participate in this study. This study was supported financially by the Children's Hospital Clinical Research Grant Program and Pharmacia & Upjohn.
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Garnett, S., Cowell, C., Baur, L. et al. Abdominal fat and birth size in healthy prepubertal children. Int J Obes 25, 1667–1673 (2001). https://doi.org/10.1038/sj.ijo.0801821
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DOI: https://doi.org/10.1038/sj.ijo.0801821
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