Skip to main content

Advertisement

SpringerLink
Log in

Treatment of testosterone-induced gynecomastia with the aromatase inhibitor, anastrozole

  • Case Report
  • Published:
International Journal of Impotence Research Submit manuscript

Abstract

Gynecomastia is an unusual side effect associated with testosterone replacement therapy (TRT) that has been traditionally treated with surgery, radiation, or discontinuation of testosterone supplementation. We report here our experience with two cases of gynecomastia in men undergoing TRT who were successfully treated with the aromatase inhibitor anastrozole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Taplin ME, Ho S-M . The endocrinology of prostate cancer. J Clin Endocrinol Metab 2001; 86: 3467–3477.

    Article  CAS  Google Scholar 

  2. Gruntmanis U, Braunstein GD . Treatment of gynecomastia. Curr Opin Invest Drugs 2001; 2: 643–649.

    CAS  Google Scholar 

  3. Raman JD, Schlegel PN . Aromatase inhibitors for male infertility. J Urol 2002; 167: 624–629.

    Article  CAS  Google Scholar 

  4. Geisler J et al. Influence of anastrozole (Arimidex), a selective, non-steroidal aromatase inhibitor on in vivo aromatization and plasma estrogen levels in postmenopausal women with breast cancer. Br J Cancer 1996; 74: 1286.

    Article  CAS  Google Scholar 

  5. Buzdar AU, Riobertson JFR, Eliermann W, Nabholtz J-M . An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane. Pharmacol Pharmacokinet 2002; 95: 2006–2016.

    CAS  Google Scholar 

  6. Gillam MP, Middler S, Freed DJ, Molitch ME . The novel use of very high doses of cabergoline and combination of testosterone and an aromatase inhibitor in the treatment of a giant prolactinoma. J Clin Endocrinol Metab 2002; 87: 4447–4451.

    Article  CAS  Google Scholar 

  7. Herzog AG, Klein P, Jacobs AR . Testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy in men with epilepsy and hypogonadism. Neurology 1998; 50: 782–784.

    Article  CAS  Google Scholar 

  8. Taxel P et al. The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men. J Clin Endocrinol Metab 2001; 86: 2869–2874.

    CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. E L Rhoden: Supported by CAPES-Brazil (Government Foundation for Development of Postgraduation courses in Brazil).

Authors and Affiliations

  1. Division of Urology, Beth Israel Deaconess Medical Center, Men's Health Boston, Harvard Medical School, Massachusetts, USA

    E L Rhoden & A Morgentaler

Authors
  1. E L Rhoden
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Morgentaler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to E L Rhoden or A Morgentaler.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rhoden, E., Morgentaler, A. Treatment of testosterone-induced gynecomastia with the aromatase inhibitor, anastrozole. Int J Impot Res 16, 95–97 (2004). https://doi.org/10.1038/sj.ijir.3901154

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijir.3901154

  • Springer Nature Limited

Keywords

This article is cited by

Search

Navigation