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DOK4 and DOK5: new dok-related genes expressed in human T cells

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Abstract

Dok proteins are adapter proteins involved in signal transduction. Several intracellular proteins expressed in lymphocytes meet the criteria of membrane-associated adapter proteins such as members of the Dok family. To understand the role and the formation of multiprotein networks involving Dok proteins in T lymphocytes, we search for potential additional members of this family. Here, we describe the two new human dok-related genes DOK4 and DOK5 and present data showing the expression of DOK4 and DOK5 genes in T cells. These genes are the orthologues of mouse Dok4 and Dok5 genes. Based on analysis of phylogenetic trees and exon/intron structure of Dok family members, DOK4 and DOK5 define a subfamily within dok genes distinct from DOK1, DOK2 and DOK3. So, Dok-4 and Dok-5 molecules constitute a new group of adapter proteins in T cells, requiring further functional analysis.

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Acknowledgements

We would like to thank Y Collette for a critical reading of this manuscript. This research was supported by the Institut National de la Santé et de la Recherche Médicale, by a grant “équipe labellisée” from the Ligue Nationale Contre le Cancer and by Grants 4330 and 5740 from the Association pour la Recherche contre le Cancer. C Favre was supported by a fellowship from the Association pour la Recherche contre le Cancer.

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  1. C Favre and A Gérard: These authors contributed equally to this work.

Authors and Affiliations

  1. U119 INSERM, Institut de Cancérologie et d'Immunologie de Marseille, Université de la Méditerranée, Marseille, France

    C Favre, A Gérard, E Clauzier, P Pontarotti, D Olive & J A Nunès

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  1. C Favre
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  2. A Gérard
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  3. E Clauzier
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  4. P Pontarotti
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  5. D Olive
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  6. J A Nunès
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Correspondence to J A Nunès.

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Favre, C., Gérard, A., Clauzier, E. et al. DOK4 and DOK5: new dok-related genes expressed in human T cells. Genes Immun 4, 40–45 (2003). https://doi.org/10.1038/sj.gene.6363891

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