Abstract
We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.
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Acknowledgements
We thank Ms Yuko Furukawa for her skilful technical assistance. We are especially grateful to Dr Motosuke Hanada for his encouragement and helpful advice.
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This research was supported by Grant-in-Aid for Scientific Research from the Ministry of Health, Labor and Welfare.
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Nakashima, H., Miyake, K., Inoue, Y. et al. Association between IL-4 genotype and IL-4 production in the Japanese population. Genes Immun 3, 107–109 (2002). https://doi.org/10.1038/sj.gene.6363830
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DOI: https://doi.org/10.1038/sj.gene.6363830
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