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A highly polymorphic CA repeat marker at the interleukin-11 locus

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Abstract

The interleukin-11 (IL-11) stimulates T cell-dependent development of immunoglobulin-producing B cells and collaborates with IL-3 in supporting murine megakaryocyte colony formation. The interleukin-11 (IL-11) also stimulates osteoclast formation and inhibits osteoclast function in vitro and has been implicated in estrogen deficiency-induced bone loss. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the IL-11 gene located at 19q13.3–q13.4. High heterozygosity (0.81) makes this polymorphism a useful marker in genetic study of disorders affecting immune response and bone metabolism.

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Authors and Affiliations

  1. Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki, 211-8533, Japan

    N Ota, T Nakajima & M Emi

  2. Department of Orthopedics, Nippon Medical School, Kawasaki-Tokyo, Japan

    N Ota, T Takeuchi & Y Shirai

Authors
  1. N Ota
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  2. T Nakajima
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  3. T Takeuchi
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  4. Y Shirai
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  5. M Emi
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Corresponding author

Correspondence to M Emi.

Additional information

This work was supported by research grants for osteoporosis from the Ministry of Health and Welfare of Japan and the Novartis Foundation for Gerontological Research.

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Ota, N., Nakajima, T., Takeuchi, T. et al. A highly polymorphic CA repeat marker at the interleukin-11 locus. Genes Immun 1, 159–160 (1999). https://doi.org/10.1038/sj.gene.6363637

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  • DOI: https://doi.org/10.1038/sj.gene.6363637

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