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An IL-13 promoter polymorphism associated with increased risk of allergic asthma

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Abstract

IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position −1055. The IL-13 −1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. we postulate that the presence of this polymorphism predisposes to the development of allergic asthma.

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Authors and Affiliations

  1. Department of Auto-Immune Diseases, CLB and Laboratory of Clinical and Experimental Immunology, University of Amsterdam, Plesmanlaan 125, Amsterdam, 1066, CX, The Netherlands

    TCTM van der Pouw Kraan, LCM Boeije, SAP van Tuyl, ER de Groot & LA Aarden

  2. Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands

    A van Veen & JS van der Zee

  3. Department of Allergy, CLB and Laboratory of Clinical and Experimental Immunology, University of Amsterdam, The Netherlands

    SO Stapel

  4. Department of Rheumatology, Academic Hospital, Leiden, The Netherlands

    A Bakker & CL Verweij

Authors
  1. TCTM van der Pouw Kraan
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  2. A van Veen
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  3. LCM Boeije
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  4. SAP van Tuyl
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  5. ER de Groot
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  6. SO Stapel
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  7. A Bakker
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  8. CL Verweij
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  9. LA Aarden
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  10. JS van der Zee
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Additional information

This study is financially supported by the Netherlands Asthma Foundation, grant No. 96.42.

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van der Pouw Kraan, T., van Veen, A., Boeije, L. et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1, 61–65 (1999). https://doi.org/10.1038/sj.gene.6363630

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  • DOI: https://doi.org/10.1038/sj.gene.6363630

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