Abstract
Objective:
Frequent consumption of nuts is associated with favorable plasma lipid profiles and reduced risk of coronary heart disease (CHD). This study was conducted to investigate the effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men compared with baseline and control diet, and also to measure the anthropometric parameters, habitual physical activities, nutrient intake and endothelial function.
Subjects and design:
Fifteen hypercholesterolemic men aged 48±8 years were recruited voluntarily. A well-controlled, 2-period (P1 and P2) study design with a total of 8-week was implemented. In the P1, subjects consumed a control diet (low-fat, low-cholesterol and high-carbohydrate). During the P2, the control diet was supplemented with MUFA-rich hazelnut (40 g/day), which provided 11.6% of total energy content. Anthropometric parameters and habitual physical activities were recorded. Plasma total and HDL cholesterol, TAG, ApoA-1, Apo B, total homocysteine and glucose concentrations were measured. All parameters and measurements were obtained at baseline and end of each 4-week diet period.
Results:
Body weights of subjects remained stable throughout the study. Compared with baseline, the hazelnut-enriched diet decreased (P<0.05) the concentrations of VLDL cholesterol, triacylglycerol, apolipoprotein B by 29.5, 31.8, and 9.2%, respectively, while increasing HDL cholesterol concentrations by 12.6%. Total/HDL cholesterol and LDL/HDL cholesterol ratios favorably decreased (P<0.05). Although insignificant there was a decreasing trend for the rest of parameters, particularly in total (5.2%) and LDL cholesterol (3.3%) in subjects consuming a hazelnut-enriched diet compared to that of the baseline. No changes were found in fasting levels of glucose, Apo A-1 and homocysteine between the control and hazelnut-enriched diets.
Conclusions:
This study demonstrated that a high-fat and high-MUFA-rich hazelnut diet was superior to a low-fat control diet because of favorable changes in plasma lipid profiles of hypercholesterolemic adult men and, thereby positively affecting the CHD risk profile.
Sponsorship:
Funding provided by a grant from the Hazelnut Promotion Group, Giresun, Turkey.
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References
Abbey M, Noakes M, Belling GB, Neste PJ (1994). Partial replacement of saturated fatty acids with almonds or walnuts lowers total plasma cholesterol and low-density-lipoprotein cholesterol. Am J Clin Nutr 59, 995–999.
Alasalvar C, Shahidi F, Cadwallader KR (2003a). Comparison of natural and roasted Turkish Tombul hazelnut (Corylus avellana L.) volatiles and flavor by DHA/GC/MS and descriptive sensory analysis. J Agric Food Chem 51, 5067–5072.
Alasalvar C, Shahidi F, Liyanapathirana CM, Ohshima T (2003b). Turkish Tombul hazelnut (Corylus avellana L.). 1. Compositional characteristics. J Agric Food Chem 51, 3790–3796.
Alasalvar C, Shahidi F, Ohshima T, Wanasundara U, Yurttas HC, Liyanapathirana CM et al. (2003c). Turkish Tombul hazelnut (Corylus avellana L.). 2. Lipid characteristics and oxidative stability. J Agric Food Chem 51, 3797–3805.
Albert CM, Gaziano JM, Willett WC, Manson JE (2002). Nut consumption and decreased risk of sudden cardiac death in the Physicians’ Health Study. Arch Intern Med 162, 1382–1387.
Almario RU, Vonghavaravat V, Wong R, Kasim-Karakas SE (2001). Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. Am J Clin Nutr 74, 72–79.
Alphan E, Pala M, Açkurt F, Yilmaz T (1997). Nutritional composition of hazelnuts and its effects on glucose and lipid metabolism. Acta Hortic 445, 305–310.
Anderson JW, Smith BM, Gustafson NJ (1994). Health benefits and practical aspects of high-fiber diets. Am J Clin Nutr 59 (Suppl), 1242S–1247S.
Austin MA, Hokanson JE, Edwards KL (1998). Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 81 (4A), 7B–12B.
Blair SN, Haskell WL, Ho P, Paffenbarger Jr RS, Vranizan KM, Farquhar JW et al. (1985). Assessment of habitual physical activity by a seven-day recall in a community survey and controlled experiments. Am J Epidemiol 122, 794–804.
Brown L, Rosner B, Willett WW, Sacks FM (1999). Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 69, 30–42.
Committee on Diet and Health, Food and Nutrition Board, Commission on Life Sciences, National Research Council (1989). Diet and Health: Implications for Reducing Chronic Disease Risk. National Academy Press: Washington, DC.
Connor WE, Connor SL, Katan MB, Grundy SM, Willett WC (1997). Should a low-fat, high-carbohydrate diet be recommended for everyone? N Engl J Med 337, 562–567.
Cooke JP, Tsao PS (1997). Arginine: a new therapy for atherosclerosis? Circulation 95, 311–312.
Davis CE, Rifkind BM, Brenner H, Gordon DJ (1990). A single cholesterol measurement underestimates the risk of coronary heart disease. An empirical example from the Lipid Research Clinics Mortality Follow-up Study. J Am Med Assoc 264, 3044–3046.
Durak I, Köksal I, Kaçmaz M, Büyükkoçak S, Çimen BMY, Öztürk HS (1999). Hazelnut supplementation enhances plasma antioxidant potential and lowers plasma cholesterol levels. Clin Chim Acta 284, 113–115.
Edwards K, Kwaw I, Matud J, Kurtz I (1999). Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. J Am Coll Nutr 18, 229–232.
Elin RJ, Hosseini JM (1993). Is the magnesium content of nuts a factor for coronary heart disease? Arch Intern Med 153, 779–780.
Feldman EB (2002). The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J Nutr 132, 1062S–1101S.
Fink PC, Romer M, Haeckel R, Fateh-Moghadam A, Delanghe J, Gressner AM et al. (1989). Measurement of proteins with the Behring Nephelometer. A multicenter evaluation. J Clin Chem Clin Biochem 27, 261–276.
Food and Drug Administration (2003). Qualified Health Claims: Letter of Enforcement Discretion – Nuts and Coronary Heart Disease. Docket No 02P-0505. Food and Drug Administration: Washington, DC.
Fraser GE, Sabaté J, Beeson WL, Strahan TM (1992). A possible protective effect of nut consumption on risk of coronary heart disease. The Adventist Health Study. Arch Intern Med 152, 1416–1424.
Friedewald WT, Levy RI, Fredrickson DS (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499–502.
Garg A, Bonanome A, Grundy SM, Zhang ZJ, Unger RH (1988). Comparision of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 319, 829–834.
Garg ML, Blake RJ, Wills RBH (2003). Macadamia nut consumption lowers plasma total and LDL cholesterol levels in hypercholesterolemic men. J Nutr 133, 1060–1063.
Ginsberg HN, Barr SL, Gilbert A, Karmally W, Deckelbaum R, Kaplan K et al. (1990). Reduction of plasma cholesterol levels in normal men on an American Heart Association Step 1 diet or a Step 1 diet with added monounsaturated fat. N Engl J Med 322, 574–579.
Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD et al. (1989). High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 79, 8–15.
Grundy SM (1986). Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. N Engl J Med 314, 745–748.
Hu FB, Stampfer MJ (1999). Nut consumption and risk of coronary heart disease: a review of epidemiologic evidence. Curr Ather Rep 1, 204–209.
Hu FB, Stampfer MJ, Manson JE, Rimm EB, Colditz GA, Rosner BA et al. (1998). Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. Br Med J 317, 1341–1345.
Hyson DA, Schneeman BO, Davis PA (2002). Almonds and almond oil have similar effects on plasma lipids and LDL oxidation in healthy men and women. J Nutr 132, 703–707.
James WPT, Schofield EC (1990). Human Energy Requirements. A Manual for Planners and Nutritionists. FAO/Oxford University Press: Oxford, UK.
Jones PJH, Mac Dougall DE, Ntanios FY, Vanstone CA (1997). Dietary phytosterols as cholesterol-lowering agents in humans. Can J Physiol Pharm 75, 217–227.
Kinosian B, Glick H, Preiss L, Puder KL (1995). Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios. J Invest Med 43, 443–450.
Klevay LM (1993). Copper in nuts may lower heart disease risk. Arch Intern Med 153, 401–402.
Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ et al. (2000). AHA dietary guidelines. Revision 2000: A statement for healthcare professionals from the nutrition committee of the American Hearth Association. Circulation 102, 2284–2299.
Kris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V et al. (1999a). High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr 70, 1009–1015.
Kris-Etherton PM, Poth SY, Sabaté J, Ratcliffe HE, Zhao G, Etherton TD (1999b). Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk. Am J Clin Nutr 70 (Suppl), 504S–511S.
Lohman TG, Roche AF, Martorell R (1988). Anthropometric Standardization Reference Manual. Human Kinetics Books: Champaign, IL.
Lovejoy JC, Most MM, Lefevre M, Greenway FL, Rood JC (2002). Effect of diets enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or type 2 diabetes. Am J Clin Nutr 76, 1000–1006.
Mahley RW, Palaoglu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V et al. (1995). Turkish Hearth Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res 36, 839–859.
Mensink RP, Katan MB (1987). Effect of monounsaturated fatty acids versus complex carbohydrates on high-density lipoproteins in healthy men and women. Lancet 1, 122–125.
NCEP Expert Panel (1993). Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). J Am Med Assoc 269, 3015–3023.
Rajaram S, Burke K, Connell B, Myint T, Sabaté J (2001). A monounsaturated fatty acid-rich pecan-enriched diet favorably alters the serum lipid profile of healthy men and women. J Nutr 131, 2275–2279.
Rimm EB, Stampfer MJ (1997). The role of antioxidants in preventive cardiology. Curr Opin Cardiol 12, 188–194.
Robinson K, Arheart K, Refsum H, Brattsröm L, Boers G, Ueland P et al. (1998). Low circulating folate and vitamin B6 concentrations. Risk factors for stroke, peripheral vascular disease, and coronary artery disease. Circulation 97, 437–443.
Roche HM, Zampelas A, Knapper JM, Webb D, Brooks C, Jackson KG et al. (1998). Effect of long-term olive oil dietary intervention on postprandial triacylglycerol and factor VII metabolism. Am J Clin Nutr 68, 552–560.
Sabaté J (2003). Nut consumption and body weight. Am J Clin Nutr 78 (Suppl), 647S–650S.
Sabaté J, Radak T, Brown Jr J (2000). The role of nuts in cardiovascular disease prevention. In: Wildman REC (ed). Handbook of Nutraceuticals and Functional Foods. CRC Press: London, UK. pp 478–495.
SAS Institute (1997). SAS/STAT User's Guide, 4th edn, SAS Institute Inc.: Cary, NC.
Scott JM (2000). Homocysteine and cardiovascular risk. Am J Clin Nutr 72, 333–334.
Shipchandler MT, Moore EG (1995). Rapid, fully automated measurement of plasma homocysteine with thw Abbott Imx® analyzer. Clin Chem 41, 991–994.
Spiller GA, Jenkins DAJ, Bosello O, Gates JE, Cragen LN, Bruce B (1998). Nuts and plasma lipids: An almond-based diet lowers LDL-C while preserving HDL-C. J Am Coll Nutr 17, 285–290.
Steinberg D, Lewis A (1997). Oxidative modification of LDL and atherogenesis. Circulation 95, 1062–1071.
Tokgözoglu SL (1999). The interaction between HDL and triglycerides. Atherosclerosis 146 (Suppl 1), S6–S7.
Weststrate JA, Meijer GW (1998). Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 52, 334–343.
Willett WC (2004). Eat, Drink, and be Healthy. The Harvard Medical School Guide to Healthy Eating. Simon and Schuster: New York, NY.
Zambón D, Sabaté J, Muñoz S, Campero B, Casals E, Merlos M et al. (2000). Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women: a randomized crossover trial. Ann Intern Med 132, 538–546.
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Mercanlıgil, S., Arslan, P., Alasalvar, C. et al. Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men. Eur J Clin Nutr 61, 212–220 (2007). https://doi.org/10.1038/sj.ejcn.1602518
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DOI: https://doi.org/10.1038/sj.ejcn.1602518
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